Special Issue "A Commemorative Issue in Honor of Professor Gregory Gregoriadis: Liposomes for the Delivery of Drugs and Vaccines"
Deadline for manuscript submissions: closed (31 August 2021).
2. Institute for Chemical Engineering Sciences, Foundation for Research and Technology Hellas, FORTH/ICE-HT, Stadiou Street, 26504 Platani-Rio, Greece
Interests: targeted drug delivery; nanomedicines; liposome technology; lipid-based formulations
Special Issues and Collections in MDPI journals
Special Issue in Pharmaceutics: Overcoming Drug Delivery Problems through Advanced Drug Delivery System Design
The therapeutic potential of certain categories of drugs, such as drugs with high molecular weight, low aqueous solubility, and/or high permeability, narrow therapeutic range and also drugs that are liable in blood and/or at the site of administration/absorption, cannot be manifested unless particular delivery challenges are overcome. The design and development of liposomal drugs may offer solutions to such delivery problems, especially if the liposomal carriers can reach, and deliver the associated drug to their specific biological targets. In addition to Drug Delivery solutions, liposomes can offer solutions to vaccination limitations. Vaccination is often hampered by the presence of infectious agents, weak immune responses and prohibiting costs, especially in the developing world. Such problems may be circumvented by immunisation with nucleic acids (eg. plasmid DNA, siRNA, mRNA), especially when associated with cationic lipids in the form of liposomes and other lipid-based nanoparticles, as exemplified by the current efforts for the prevention of Covid 19 virus pandemic. The contributors of the present volume deal with the background and progress made so far with liposomes for drug delivery and targeting, as well as vaccines, (especially nucleic acid vaccines). Theoretical and practical advantages as well as potential risks are discussed.
- liposomes for drug delivery (for therapy of cancer, infectious diseases, neurodegenerative diseases, etc.)
- development, applications, and challenges of ligand-targeted liposomal drugs
- liposomes and biological barriers
- liposomes as immunological adjuvants
- cationic liposomes and lipid nanoparticles as vaccine carriers
- immunization with nucleic acids in liposomes
- entrapment of nucleic acid vaccines in cationic liposomes