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Pharmaceutics
Special Issues
Polymer Nanogels for Controlled Drug Delivery
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Polymer Nanogels for Controlled Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 2839

Special Issue Editor

Prof. Dr. Mark Edward Byrne

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Henry M. Rowan College of Engineering, Rowan University, Glassboro, NJ 08028, USA
Interests: biomaterials engineering; biomimetic & biohybrid materials engineering; polymer engineering; pharmaceutical engineering; therapeutic delivery

Special Issue Information

Dear Colleagues,

Nanogels are robust swollen cross-linked polymer nanoparticles that can be used as highly efficient and biodegradable carriers for the transport of drugs in controlled drug delivery. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery.

In this Special Issue, we discuss the description of the design, synthesis and drug delivery application properties of polymer nanogels. We focus on preparation and application of diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive) nanogels, which enable the stimuli-responsive release of drugs in the microenvironments of various diseases. And the synthesized nanosystems for tumor targeting modified by specific ligands.

Prof. Dr. Mark Edward Byrne
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanogels
  • polymer nanogels
  • multifunctional nanogels
  • drug delivery
  • drug release
  • stimuli-responsive

Published Papers (1 paper)

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Research

32 pages, 7173 KiB  
Article
Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery
by Siyuan Deng, Maria Rosa Gigliobianco, Emin Mijit, Marco Minicucci, Manuela Cortese, Barbara Campisi, Dario Voinovich, Michela Battistelli, Sara Salucci, Pietro Gobbi, Giulio Lupidi, Giorgia Zambito, Laura Mezzanotte, Roberta Censi and Piera Di Martino
Pharmaceutics 2021, 13(12), 2048; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13122048 - 30 Nov 2021
Cited by 3 | Viewed by 2407
Abstract
A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by [...] Read more.
A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by a water in oil nanoemulsion method using two biocompatible synthetic polymers: vinyl sulfonated poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate)-polyethylene glycol-poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate) triblock copolymer, and thiolated hyaluronic acid. The influence on the nanohydrogel particle size and distribution of formulation parameters was investigated by a three-level full factorial design to optimize the preparation conditions. The surface and core-shell morphology of the nanohydrogel were observed by scanning electron microscope, transmission electron microscopy, and further confirmed by Fourier transform infrared spectroscopy and Raman spectroscopy from the standpoint of chemical composition. The redox-responsive biodegradability of the nanohydrogel in reducing environments was determined using glutathione as reducing agent. A nanohydrogel with particle size around 250 nm and polydispersity index around 0.1 is characterized by a thermosensitive shell which jellifies at body temperature and crosslinks at the interface of a redox-responsive hyaluronic acid core via the Michael addition reaction. The nanohydrogel showed good encapsulation efficiency for model macromolecules of different molecular weight (93% for cytochrome C, 47% for horseradish peroxidase, and 90% for bovine serum albumin), capacity to retain the peroxidase-like enzymatic activity (around 90%) of cytochrome C and horseradish peroxidase, and specific redox-responsive release behavior. Additionally, the nanohydrogel exhibited excellent cytocompatibility and internalization efficiency into macrophages. Therefore, the developed core-shell structure nanohydrogel can be considered a promising tool for the potential intracellular delivery of different pharmaceutical applications, including for cancer therapy. Full article
(This article belongs to the Special Issue Polymer Nanogels for Controlled Drug Delivery)
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