Special Issue "Advances in Pharmaceutical Solid Forms"
Deadline for manuscript submissions: 30 April 2022.
Interests: solid state chemistry; co-crystal science; active pharmaceutical ingredient and excipient stability; polymorphs screening; nanomedicine; drug formulation; physical chemistry of pharmaceutical ingredients; pharmacokinetics; in vitro dissolution studies; nanocrystals; nanoemulsions
Solubility enhancement of poorly water-soluble drugs is a major challenge in the pharmaceutical field since 80% of the marketed drugs are formulated in solid state and more than 70% of the drugs in development exhibit low solubility (BCS class II and IV). Nevertheless, solid dosage forms are widely favored, mainly due to stability issues of the active ingredients.
A broad and comprehensive study of various solid forms of the pharmaceutical matter is needed to enhance their clinical translation with optimized success. Indeed, the most suitable solid forms have to be taken into consideration regarding their stability and bioavailability.
Many matter modification processes in the solid state, such as salts, solid solutions, scalemic mixtures, amorphous, polymorphs, solvatomorphs, nanocrystals, guest-host assemblies, nanocarriers, and cocrystals formation, have been adapted to challenge and improve both drug substance loading capacity and bioavailability. Each system presents its own advantages and drawbacks, depending on the administration route, the therapeutic target, the release rate of the drug, the final product manufacturing, and the cost of production; the objective behind this survey is to enhance the benefice/risk ratio of innovative formulation for adaptative treatments.
Reviews and original articles dealing with the modulation of pharmaceutical solid dosage forms (with organic or inorganic active ingredients) for formulation, storage, and therapeutic effect enhancement are encouraged for publication in this Special Issue of Pharmaceutics.
Dr. Yohann Corvis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- salt formation
- solvate/hydrate formation
- size reduction
- solid solutions
- solid suspensions
- enantiomeric vs. racemic drugs
- active ingredient: excipient interactions
- active ingredient: active ingredient interactions