Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications
share announcement

Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 6186

Special Issue Editors

Dr. Adérito J. R. Amaral

E-Mail Website
Guest Editor
CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: biomaterials; bioprinting; in vitro models; self-healing hydrogels; stimuli-responsive polymers
Dr. Rosemeyre A. Cordeiro

E-Mail
Guest Editor
Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
Interests: polymer-based nanovector; mesoporous silica nanoparticles; multifunctional plaftorms for drug and gene delivery; cancer therapy; biomaterials

Special Issue Information

Dear Colleagues,

The interplay between biomaterials and components of biological origin (e.g., cells, proteins and nucleic acids) constitutes a rich topic of interest that can aid the investigation of specific cellular functions and cues for therapeutic and research purposes in a spatiotemporally controlled manner. “Smart” polymers, which can reversibly change their physico-chemical properties in response to the application of external stimuli, and inorganic nanoparticles encompass an extensive library of building blocks that can lead to the design of hybrid, multi-responsive constructs that are important in the biomedical field, ranging from nanocarriers and biosensors for precision medicine, to material ensembles and injectable fillers for cell-based therapies, tissue engineering and three-dimensional (3D) in vitro modelling. We invite scientists worldwide to contribute to this Special Issue with articles that concern the most recent advancements in stimuli-sensitive biomaterials for pharmaceutical and biomedical applications.

Dr. Adérito J. R. Amaral
Dr. Rosemeyre A. Cordeiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • responsive polymers
  • hydrogels
  • nanoparticles
  • biofabrication
  • controlled drug delivery
  • tissue engineering
  • gene therapy

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

20 pages, 12953 KiB  
Article
Modified Sulfanilamide Release from Intelligent Poly(N-isopropylacrylamide) Hydrogels
by Ana Dinić, Vesna Nikolić, Ljubiša Nikolić, Snežana Ilić-Stojanović, Stevo Najman, Maja Urošević and Ivana Gajić
Pharmaceutics 2023, 15(6), 1749; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15061749 - 16 Jun 2023
Viewed by 981
Abstract
The aim of this study was to examine homopolymeric poly(N-isopropylacrylamide), p(NIPAM), hydrogels cross-linked with ethylene glycol dimethacrylate as carriers for sulfanilamide. Using FTIR, XRD and SEM methods, structural characterization of synthesized hydrogels before and after sulfanilamide incorporation was performed. The residual [...] Read more.
The aim of this study was to examine homopolymeric poly(N-isopropylacrylamide), p(NIPAM), hydrogels cross-linked with ethylene glycol dimethacrylate as carriers for sulfanilamide. Using FTIR, XRD and SEM methods, structural characterization of synthesized hydrogels before and after sulfanilamide incorporation was performed. The residual reactants content was analyzed using the HPLC method. The swelling behavior of p(NIPAM) hydrogels of different crosslinking degrees was monitored in relation to the temperature and pH values of the surrounding medium. The effect of temperature, pH, and crosslinker content on the sulfanilamide release from hydrogels was also examined. The results of the FTIR, XRD, and SEM analysis showed that sulfanilamide is incorporated into the p(NIPAM) hydrogels. The swelling of p(NIPAM) hydrogels depended on the temperature and crosslinker content while pH had no significant effect. The sulfanilamide loading efficiency increased with increasing hydrogel crosslinking degree, ranging from 87.36% to 95.29%. The sulfanilamide release from hydrogels was consistent with the swelling results—the increase of crosslinker content reduced the amount of released sulfanilamide. After 24 h, 73.3–93.5% of incorporated sulfanilamide was released from the hydrogels. Considering the thermosensitivity of hydrogels, volume phase transition temperature close to the physiological temperature, and the satisfactory results achieved for sulfanilamide incorporation and release, it can be concluded that p(NIPAM) based hydrogels are promising carriers for sulfanilamide. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications)
►▼ Show Figures

Figure 1

19 pages, 5222 KiB  
Article
Novel Oxygen- and Curcumin-Laden Ionic Liquid@Silica Nanocapsules for Enhanced Antimicrobial Photodynamic Therapy
by Joana Henriques, João Pina, Mara E. M. Braga, Ana M. A. Dias, Patrícia Coimbra and Hermínio C. de Sousa
Pharmaceutics 2023, 15(4), 1080; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15041080 - 28 Mar 2023
Viewed by 1605
Abstract
The efficiency of photodynamic therapy is often limited by the scarcity of oxygen at the target site. To address this problem, this work proposes the development of a new nanosystem for antimicrobial photodynamic therapy applications (aPDT) where the natural-origin photosensitizer curcumin (CUR) is [...] Read more.
The efficiency of photodynamic therapy is often limited by the scarcity of oxygen at the target site. To address this problem, this work proposes the development of a new nanosystem for antimicrobial photodynamic therapy applications (aPDT) where the natural-origin photosensitizer curcumin (CUR) is immersed in an oxygen-rich environment. Inspired by the perfluorocarbon-based photosensitizer/O2 nanocarriers reported in the literature, we developed a new type of silica nanocapsule containing curcumin dissolved in three hydrophobic ionic liquids (ILs) with high oxygen dissolving capacities. The nanocapsules (CUR-IL@ncSi), prepared by an original oil-in-water microemulsion/sol-gel method, had a high IL content and exhibited clear capacities to dissolve and release significant amounts of oxygen, as demonstrated by deoxygenation/oxygenation studies. The ability of CUR-IL solutions and of CUR-IL@ncSi to generate singlet oxygen (1O2) upon irradiation was confirmed by the detection of 1O2 phosphorescence at 1275 nm. Furthermore, the enhanced capacities of oxygenated CUR-IL@ncSi suspensions to generate 1O2 upon irradiation with blue light were confirmed by an indirect spectrophotometric method. Finally, preliminary microbiological tests using CUR-IL@ncSi incorporated into gelatin films showed the occurrence of antimicrobial effects due to photodynamic inactivation, with their relative efficiencies depending on the specific IL in which curcumin was dissolved. Considering these results, CUR-IL@ncSi has the potential to be used in the future to develop biomedical products with enhanced oxygenation and aPDT capacities. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications)
►▼ Show Figures

Figure 1

15 pages, 2011 KiB  
Article
Complexation of a Polypeptide-Polyelectrolytes Bioparticle as a Biomaterial of Antibacterial Activity
by Carlos A. B. Ramirez, Mateus M. Carriero, Fernanda S. C. Leomil, Ricardo L. Moro de Sousa, Antonio de Miranda, Omar Mertins and Patrick D. Mathews
Pharmaceutics 2022, 14(12), 2746; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics14122746 - 08 Dec 2022
Cited by 4 | Viewed by 1110
Abstract
The development of biomaterials to enable application of antimicrobial peptides represents a strategy of high and current interest. In this study, a bioparticle was produced by the complexation between an antimicrobial polypeptide and the biocompatible and biodegradable polysaccharides chitosan-N-arginine and alginate, [...] Read more.
The development of biomaterials to enable application of antimicrobial peptides represents a strategy of high and current interest. In this study, a bioparticle was produced by the complexation between an antimicrobial polypeptide and the biocompatible and biodegradable polysaccharides chitosan-N-arginine and alginate, giving rise to a colloidal polyelectrolytic complex of pH-responsive properties. The inclusion of the polypeptide in the bioparticle structure largely increases the binding sites of complexation during the bioparticles production, leading to its effective incorporation. After lyophilization, detailed evaluation of colloidal structure of redispersed bioparticles evidenced nano or microparticles with size, polydispersity and zeta potential dependent on pH and ionic strength, and the dependence was not withdrawn with the polypeptide inclusion. Significant increase of pore edge tension in giant vesicles evidenced effective interaction of the polypeptide-bioparticle with lipid model membrane. Antibacterial activity against Aeromonas dhakensis was effective at 0.1% and equal for the isolated polypeptide and the same complexed in bioparticle, which opens perspectives to the composite material as an applicable antibacterial system. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications)
►▼ Show Figures

Figure 1

Review

Jump to: Research

37 pages, 2241 KiB  
Review
4D Printing: The Development of Responsive Materials Using 3D-Printing Technology
by Pablo Edmundo Antezana, Sofia Municoy, Gabriel Ostapchuk, Paolo Nicolás Catalano, John G. Hardy, Pablo Andrés Evelson, Gorka Orive and Martin Federico Desimone
Pharmaceutics 2023, 15(12), 2743; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15122743 - 07 Dec 2023
Cited by 4 | Viewed by 1959
Abstract
Additive manufacturing, widely known as 3D printing, has revolutionized the production of biomaterials. While conventional 3D-printed structures are perceived as static, 4D printing introduces the ability to fabricate materials capable of self-transforming their configuration or function over time in response to external stimuli [...] Read more.
Additive manufacturing, widely known as 3D printing, has revolutionized the production of biomaterials. While conventional 3D-printed structures are perceived as static, 4D printing introduces the ability to fabricate materials capable of self-transforming their configuration or function over time in response to external stimuli such as temperature, light, or electric field. This transformative technology has garnered significant attention in the field of biomedical engineering due to its potential to address limitations associated with traditional therapies. Here, we delve into an in-depth review of 4D-printing systems, exploring their diverse biomedical applications and meticulously evaluating their advantages and disadvantages. We emphasize the novelty of this review paper by highlighting the latest advancements and emerging trends in 4D-printing technology, particularly in the context of biomedical applications. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Materials for Biomedical and Pharmaceutical Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop