Special Issue "Viral Subversion of Stress Responses and Translational Control"
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (29 February 2016).
Interests: influenza A virus; Kaposi’s sarcoma-associated herpesvirus; viral oncogenes; mRNA turnover and translation; stress granules; p-bodies; autophagy; unfolded protein response; inflammation; host shutoff
Special Issues, Collections and Topics in MDPI journals
Special Issue in Viruses: The Role of NK Cells in Antiviral Innate Immunity
Special Issue in Viruses: Viruses and the Unfolded Protein Response
The cellular translation apparatus swiftly responds to changing environmental conditions, altering gene expression to promote survival in times of stress, and restoring homeostasis following stress resolution. Accumulating evidence indicates that the translation apparatus is a nexus for control of antiviral responses. Viruses are obligate intracellular parasites that repurpose the host translation apparatus for efficient conversion of viral mRNAs into protein products. Sentinel pattern-recognition receptors and associated kinases sense viral infection and activate antiviral defences that include near-global shutdown of cap-dependent translation, thereby limiting accumulation of viral proteins. Coincident signal transduction events lead to the production of interferon, eliciting a local antiviral state. The molecular mechanisms that coordinate these responses remain incompletely understood.
In recent years, many viral countermeasures have been identified that limit activation of innate antiviral stress responses and maintain ongoing translation of viral gene products. This Special Issue of Viruses is dedicated to understanding how successful viruses subvert these antiviral responses. We hope to assemble a collection of research papers and reviews that enhance our understanding of these fascinating host defences and viral countermeasures. Topics may include studies on the evolution and function of innate antiviral stress responses and/or viral countermeasures; viral mechanisms of host shutoff and direct control of the translation apparatus; viral control of host stress responses intimately linked with translation, including DNA damage responses, hypoxia, autophagy and the unfolded protein response; and impact of these interactions on cell fate and a variety of pathogenic outcomes of infection, including cancer.
We hope that this Special Issue will serve as a valuable resource to new and established researchers in the field, and frame important unanswered questions to focus future research efforts.
Dr. Craig McCormick
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- translation control
- host shutoff
- alternative viral translation mechanisms
- antiviral defences
- unfolded protein response