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Review

Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer

1
Center of Medical Innovation and Translational Research, Department of Medical Data Science, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan
2
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
3
Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Santo Andrea Hospital, Via di Grottarossa, 1035-00189 Rome, Italy
4
Unitech Co., Ltd., Kashiwa 277-0005, Japan
5
Kyowa-kai Medical Corporation, Osaka 540-0008, Japan
6
Food and Life-Science Laboratory, Prophoenix Division, Idea Consultants, Inc., Osaka 559-8519, Japan
7
Kinshu-kai Medical Corporation, Osaka 558-0041, Japan
8
Hirotsu Bio Science Inc., Tokyo 107-0062, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Sabrina Battistas
Int. J. Mol. Sci. 2021, 22(14), 7278; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147278
Received: 5 June 2021 / Revised: 1 July 2021 / Accepted: 2 July 2021 / Published: 6 July 2021
(This article belongs to the Special Issue Diet and Metabolism: Molecular Mechanisms of Health and Disease)
One-carbon (1C) metabolism plays a key role in biological functions linked to the folate cycle. These include nucleotide synthesis; the methylation of DNA, RNA, and proteins in the methionine cycle; and transsulfuration to maintain the redox condition of cancer stem cells in the tumor microenvironment. Recent studies have indicated that small therapeutic compounds affect the mitochondrial folate cycle, epitranscriptome (RNA methylation), and reactive oxygen species reactions in cancer cells. The epitranscriptome controls cellular biochemical reactions, but is also a platform for cell-to-cell interaction and cell transformation. We present an update of recent advances in the study of 1C metabolism related to cancer and demonstrate the areas where further research is needed. We also discuss approaches to therapeutic drug discovery using animal models and propose further steps toward developing precision cancer medicine. View Full-Text
Keywords: one-carbon metabolism; amino acids; epitranscriptome; tumor; microenvironment one-carbon metabolism; amino acids; epitranscriptome; tumor; microenvironment
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MDPI and ACS Style

Takeda, Y.; Chijimatsu, R.; Vecchione, A.; Arai, T.; Kitagawa, T.; Ofusa, K.; Yabumoto, M.; Hirotsu, T.; Eguchi, H.; Doki, Y.; Ishii, H. Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer. Int. J. Mol. Sci. 2021, 22, 7278. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147278

AMA Style

Takeda Y, Chijimatsu R, Vecchione A, Arai T, Kitagawa T, Ofusa K, Yabumoto M, Hirotsu T, Eguchi H, Doki Y, Ishii H. Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer. International Journal of Molecular Sciences. 2021; 22(14):7278. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147278

Chicago/Turabian Style

Takeda, Yu, Ryota Chijimatsu, Andrea Vecchione, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Hidetoshi Eguchi, Yuichiro Doki, and Hideshi Ishii. 2021. "Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer" International Journal of Molecular Sciences 22, no. 14: 7278. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147278

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