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Open AccessArticle

Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity

1
Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
2
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
3
Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan
4
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Iolanda Francolini and Antonella Piozzi
Int. J. Mol. Sci. 2021, 22(3), 1139; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031139
Received: 4 January 2021 / Revised: 21 January 2021 / Accepted: 21 January 2021 / Published: 24 January 2021
(This article belongs to the Special Issue Chitosan Functionalizations, Formulations and Composites 2.0)
Chitosan and its derivative, chitosan oligosaccharide (CO), possess hypolipidemic and anti-obesity effects. However, it is still unclear if the mechanisms are different or similar between chitosan and CO. This study was designed to investigate and compare the effects of CO and high-molecular-weight chitosan (HC) on liver lipogenesis and lipid peroxidation, adipose lipolysis, and intestinal lipid absorption in high-fat (HF) diet-fed rats for 12 weeks. Rats were divided into four groups: normal control diet (NC), HF diet, HF diet+5% HC, and HF diet+5% CO. Both HC and CO supplementation could reduce liver lipid biosynthesis, but HC had a better effect than CO on improving liver lipid accumulation in HF diet-fed rats. The increased levels of triglyceride decreased lipolysis rate, and increased lipoprotein lipase activity in the perirenal adipose tissue of HF diet-fed rats could be significantly reversed by both HC and CO supplementation. HC, but not CO, supplementation promoted liver antioxidant enzymes glutathione peroxidase and superoxide dismutase activities and reduced liver lipid peroxidation. In the intestines, CO, but not HC, supplementation reduced lipid absorption by reducing the expression of fabp2 and fatp4 mRNA. These results suggest that HC and CO have different mechanisms for improving lipid metabolism in HF diet-fed rats. View Full-Text
Keywords: high-molecular-weight chitosan; chitosan oligosaccharide; high-fat diet-fed rats; lipid metabolism high-molecular-weight chitosan; chitosan oligosaccharide; high-fat diet-fed rats; lipid metabolism
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MDPI and ACS Style

Liu, S.-H.; Chen, R.-Y.; Chiang, M.-T. Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity. Int. J. Mol. Sci. 2021, 22, 1139. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031139

AMA Style

Liu S-H, Chen R-Y, Chiang M-T. Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity. International Journal of Molecular Sciences. 2021; 22(3):1139. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031139

Chicago/Turabian Style

Liu, Shing-Hwa; Chen, Rui-Yi; Chiang, Meng-Tsan. 2021. "Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity" Int. J. Mol. Sci. 22, no. 3: 1139. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031139

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