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Article

Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin

1
Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland
2
Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland
3
Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Marek J. Łos
Int. J. Mol. Sci. 2021, 22(3), 1202; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031202
Received: 28 December 2020 / Revised: 21 January 2021 / Accepted: 22 January 2021 / Published: 26 January 2021
(This article belongs to the Special Issue Recent Advances in Biotechnology)
Amphiphilic copolymers containing polydimethylsiloxane (PDMS) and polyethylene glycol methyl ether (MPEG) were obtained via an azide-alkyne cycloaddition reaction between alkyne-functionalized copolymer of MPEG methacrylate and azide-functionalized PDMS. “Click” reactions were carried out with an efficiency of 33–47% increasing grafting degrees. The grafted copolymers were able to carry out the micellization and encapsulation of active substances, such as vitamin C (VitC), ferulic acid (FA) and arginine (ARG) with drug loading content (DLC) in the range of 2–68% (VitC), and 51–89% (FA or ARG). In vitro release studies (phosphate buffer saline, PBS; pH = 7.4 or 5.5) demonstrated that the maximum release of active substances was mainly after 1–2 h. The permeability of released active substances through membrane mimicking skin evaluated by transdermal tests in Franz diffusion cells indicated slight diffusion into the solution (2–16%) and their remaining in the membrane. Studies on the selected carrier with FA showed no negative effect on cell viability, proliferation capacity or senescence, as well as cell apoptosis/necrosis differences or cell cycle interruption in comparison with control cells. These results indicated that the presented micellar systems are good candidates for carriers of cosmetic substances according to physicochemical characterization and biological studies. View Full-Text
Keywords: polydimethylsiloxane; heterografted copolymers; micellar carriers; Franz diffusion cells; cytotoxicity polydimethylsiloxane; heterografted copolymers; micellar carriers; Franz diffusion cells; cytotoxicity
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MDPI and ACS Style

Odrobińska, J.; Skonieczna, M.; Neugebauer, D. Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin. Int. J. Mol. Sci. 2021, 22, 1202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031202

AMA Style

Odrobińska J, Skonieczna M, Neugebauer D. Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin. International Journal of Molecular Sciences. 2021; 22(3):1202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031202

Chicago/Turabian Style

Odrobińska, Justyna, Magdalena Skonieczna, and Dorota Neugebauer. 2021. "Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin" International Journal of Molecular Sciences 22, no. 3: 1202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22031202

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