Cancers, Volume 13, Issue 2 (January-2 2021) – 201 articles
Cover Story (view full-size image): In recent decades, an extensive body of work has provided evidence that PrPC contributes to tumorigenesis by regulating tumor growth, differentiation, and resistance to conventional therapies. PrPC overexpression has been related to the acquisition of a malignant phenotype of cancer stem cells in various solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Here, we review these data while adding novel evidence concerning PrPC expression within human PDAC and dissecting PrPC conversion into the misfolded scrapie-like conformation (PrPSc). Of note, we added novel evidence showing that in human PDAC patients, but not controls, the increase in PrPSc is in excess compared to that measured for the folded PrPC. View this paper.
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