The Search for Antimicrobial Agents from Natural Products

Dear Colleagues,

Traditionally, there has been a growing interest in exploring natural products as a reservoir of unique chemical structures that have been finely honed by evolution for their capacity to interact with biological molecular targets. Derived from diverse sources such as plants, fungi, marine organisms, and microorganisms, these natural compounds offer a treasure trove of bioactive molecules with the potential to serve as potent antimicrobial agents. This exploration into the therapeutic potential of natural products not only provides a promising avenue for combating antimicrobial resistance but also presents opportunities to circumvent the limitations associated with conventional antibiotics.

This Special Issue underscores the interdisciplinary nature of natural product research, drawing upon insights from chemistry, biochemistry, microbiology, pharmacology, and bioinformatics to accelerate the discovery and development of novel antimicrobial agents. Moreover, this Special Issue delves into the underlying mechanisms of action driving the antimicrobial efficacy of natural products, providing insights into their molecular interactions and therapeutic potential. By unraveling the intricate interplay between these compounds and microbial targets, researchers aim to harness their full therapeutic potential while minimizing the risk of resistance development. By highlighting the unique chemical structures and evolutionary adaptations of these compounds, we hope to inspire further exploration and innovation in this dynamic field, ultimately paving the way for the development new antimicrobial agents.

Dr. Carolina P. Reyes
Dr. Antonio Francioso
Guest Editors

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• natural products
• antimicrobial agents
• drug discovery
• mechanism of action
• pharmacology