Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Research of Bacteriophages Antimicrobial Activity
share announcement

Research of Bacteriophages Antimicrobial Activity

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Bacteriophages".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 3138

Special Issue Editor

Dr. Barbara Dolegowska

E-Mail Website
Guest Editor
Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland
Interests: bacteriophages; biofilms; oxidative stress; renal transplantation; phage antibiotic synergy

Special Issue Information

Dear Colleagues,

The bacteriophages are our allies in the fight against drug-resistant bacteria that deserve our undivided attention. In particular, the ability of phages to infect and destroy bacterial cells poses a possibility to replace traditional antimicrobial therapies or to use them together within phage antibiotic combined therapy. A great deal of phage research also reveals the unique evolutionary trajectories and their important role in shaping the environmental microbiome. This Special Issue seeks manuscript submissions that further our understanding of the antimicrobial activity of the bacteriophages. Submissions on the bacteriophage biology, role of phages in shaping the human/animal microbiome, phage genetic engineering, bacterial host resistance, the influence of external factor on phage activity, and phage-antibiotic synergy are especially encouraged.

Dr. Barbara Dolegowska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacteriophages
  • phage therapy
  • phage ecology, phage biocontrol
  • phage antibiotic synergy
  • antimicrobial resistance
  • phages protein
  • endolysisns

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 2422 KiB  
Article
Characterization of a Novel Bacteriophage Henu2 and Evaluation of the Synergistic Antibacterial Activity of Phage-Antibiotics
by Xianghui Li, Tongxin Hu, Jiacun Wei, Yuhua He, Abualgasim Elgaili Abdalla, Guoying Wang, Yanzhang Li and Tieshan Teng
Antibiotics 2021, 10(2), 174; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020174 - 09 Feb 2021
Cited by 13 | Viewed by 2654
Abstract
Staphylococcus aureus phage Henu2 was isolated from a sewage sample collected in Kaifeng, China, in 2017. In this study, Henu2, a linear double-stranded DNA virus, was sequenced and found to be 43,513 bp long with 35% G + C content and 63 putative [...] Read more.
Staphylococcus aureus phage Henu2 was isolated from a sewage sample collected in Kaifeng, China, in 2017. In this study, Henu2, a linear double-stranded DNA virus, was sequenced and found to be 43,513 bp long with 35% G + C content and 63 putative open reading frames (ORFs). Phage Henu2 belongs to the family Siphoviridae and possesses an isometric head (63 nm in diameter). The latent time and burst size of Henu2 were approximately 20 min and 7.8 plaque forming unit (PFU)/infected cells. The Henu2 maintained infectivity over a wide range of temperature (10–60 °C) and pH values (4–12). Phylogenetic and comparative genomic analyses indicate that Staphylococcus aureus phage Henu2 should be a new member of the family of Siphoviridae class-II. In this paper, Phage Henu2 alone exhibited weak inhibitory activity on the growth of S. aureus. However, the combination of phage Henu2 and some antibiotics or oxides could effectively inhibit the growth of S. aureus, with a decrease of more than three logs within 24 h in vitro. These results provide useful information that phage Henu2 can be combined with antibiotics to increase the production of phage Henu2 and thus enhance the efficacy of bacterial killing. Full article
(This article belongs to the Special Issue Research of Bacteriophages Antimicrobial Activity)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop