Feature Review Papers in Fermentation Process Design 2023

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Fermentation Process Design".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6235

Special Issue Editor


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Guest Editor
Department of Environmental Engineering and Earth Sciences, Clemson University, Clemson, SC, USA
Interests: bioprocess engineering; industrial microbiology; biofuels; biobased products; fermentation process development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For a long time, many microorganisms have been known for their capability to synthesize both small and large molecules that are of tremendous benefits to humankind. Thousands of years ago, ethanol and methane, which are two of many microbial products, were discovered and used by humans as a beverage and a fuel source for heating and cooking, respectively. However, fully realizing the potential of microorganisms as manufacturing bio-factories could not occur until industrial fermentation processes were developed and optimized by applied microbiologists and biochemical engineers. Perhaps two of the earliest examples of these achievements should be attributed to the large-scale production of penicillin in the deep-tank fermenters in the United States toward the end of the Second World War and the launch of the fermentation industry for amino acid production in Japan after the war. Since then, many industrial fermentation processes have been developed and implemented, which employ a wide array of biocatalysts including bacteria, yeast, microalgae, and mammalian and plant cell cultures.   

This Special Issue aims to collect high-quality review papers in all areas of fermentation process design. We encourage you, as researchers from these and related fields, to contribute review papers highlighting the latest development and design of fermentation processes, or to invite relevant experts and your colleagues to do so. Full-length comprehensive reviews will be preferred.

All submitted manuscripts will be subjected to a thorough peer-review process conducted by our invited reviewers from the industry and academia. We will maintain a high standard for our entire review process but we will also try to make efforts for speedy publication of accepted manuscripts.

We look forward to receiving your response and would like to thank you for your consideration of our Special Issue for your next manuscript.

Let us share the science as widely as possible.

Dr. Nhuan Nghiem
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Review

17 pages, 1345 KiB  
Review
Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization
by Tiffany-Marie D. Baako, Sahil Kaushik Kulkarni, Jerome L. McClendon, Sarah W. Harcum and Jordon Gilmore
Fermentation 2024, 10(5), 234; https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation10050234 - 27 Apr 2024
Viewed by 420
Abstract
The use of machine learning and deep learning has become prominent within various fields of bioprocessing for countless modeling and prediction tasks. Previous reviews have emphasized machine learning applications in various fields of bioprocessing, including biomanufacturing. This comprehensive review highlights many of the [...] Read more.
The use of machine learning and deep learning has become prominent within various fields of bioprocessing for countless modeling and prediction tasks. Previous reviews have emphasized machine learning applications in various fields of bioprocessing, including biomanufacturing. This comprehensive review highlights many of the different machine learning and multivariate analysis techniques that have been utilized within Chinese hamster ovary cell biomanufacturing, specifically due to their rising significance in the industry. Applications of machine and deep learning within other bioprocessing industries are also briefly discussed. Full article
(This article belongs to the Special Issue Feature Review Papers in Fermentation Process Design 2023)
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32 pages, 1306 KiB  
Review
Advances and Perspectives in Biohydrogen Production from Palm Oil Mill Effluent
by Marcela Moreira Albuquerque, Walter Jose Martinez-Burgos, Gabriela De Bona Sartor, Luiz Alberto Junior Letti, Júlio Cesar De Carvalho, Carlos Ricardo Soccol and Adriane Bianchi Pedroni Medeiros
Fermentation 2024, 10(3), 141; https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation10030141 - 01 Mar 2024
Viewed by 1167
Abstract
Palm oil, the main vegetable oil produced globally, serves diverse purposes, ranging from cooking to the production of processed foods, cosmetics, and biodiesel. Despite contributing significantly to the economies of major producing nations, the escalating production of palm oil raises serious environmental concerns, [...] Read more.
Palm oil, the main vegetable oil produced globally, serves diverse purposes, ranging from cooking to the production of processed foods, cosmetics, and biodiesel. Despite contributing significantly to the economies of major producing nations, the escalating production of palm oil raises serious environmental concerns, including deforestation, biodiversity loss, and various forms of pollution. Palm oil mill effluent (POME), a byproduct of palm oil extraction, poses a severe environmental threat when left untreated. As an eco-friendly alternative, anaerobic digestion in controlled bioreactors has emerged, offering simultaneous POME treatment and biofuel generation, particularly hydrogen, with high energy efficiency. This review explores the challenges and opportunities associated with biohydrogen production from POME. Key considerations involve optimizing parameters through pretreatments, nanoparticle incorporation, defining optimal bioreactor conditions, determining hydraulic retention times, and integrating multi-stage processes like dark fermentation followed by photofermentation. This review also emphasizes the significance of sustainable practices and economic analyses in shaping the future of hydrogen production from POME, positioning it as a pivotal player in the palm oil industry’s circular economy and the global energy transition. Full article
(This article belongs to the Special Issue Feature Review Papers in Fermentation Process Design 2023)
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12 pages, 912 KiB  
Review
Additivities for Soluble Recombinant Protein Expression in Cytoplasm of Escherichia coli
by Denis L. Atroshenko, Egor P. Sergeev, Diana I. Golovina and Anastasia A. Pometun
Fermentation 2024, 10(3), 120; https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation10030120 - 22 Feb 2024
Viewed by 2161
Abstract
Recombinant protein expression in Escherichia coli is a fundamental technique in molecular biology and biotechnology. This review provides a comprehensive overview of various additivities to enhance the expression levels of soluble recombinant proteins in E. coli. The discussion encompasses five key aspects. [...] Read more.
Recombinant protein expression in Escherichia coli is a fundamental technique in molecular biology and biotechnology. This review provides a comprehensive overview of various additivities to enhance the expression levels of soluble recombinant proteins in E. coli. The discussion encompasses five key aspects. Inducer Optimization: strategies for optimizing the inducer concentration to enhance protein expression. Autoinduction system optimization: the examination of glucose, lactose, and glycerol optimization within autoinduction systems to improve protein production. Osmolytes and osmoprotectants: an analysis of the use of osmolytes and osmoprotectants, such as sorbitol and glycine-betaine, to overcome with ease osmotic stress and enhance protein solubility. Ethanol additives: the impact of ethanol on E. coli physiology and its potential to improve recombinant protein expression. Cofactors and metabolic precursors: insights into the addition of cofactors, such as pyridoxal phosphate, riboflavin, thiamine, and pyridoxine, and the utilization of metabolic precursors to enhance the corresponding protein expression. This review highlights both the successful strategies and challenges in recombinant protein expression and provides insights into potential future research directions. Understanding and optimizing these factors is crucial for the efficient production of recombinant proteins for various applications in biotechnology. Furthermore, based on the analyzed data, we propose a straightforward scheme to optimize the additives in the cultivation medium. Full article
(This article belongs to the Special Issue Feature Review Papers in Fermentation Process Design 2023)
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14 pages, 1191 KiB  
Review
Recent Advancements and Strategies of Improving CO2 Utilization Efficiency in Bio-Succinic Acid Production
by Xin Chen, Hao Wu, Ying Chen, Jingwen Liao, Wenming Zhang and Min Jiang
Fermentation 2023, 9(11), 967; https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation9110967 - 10 Nov 2023
Cited by 1 | Viewed by 1682
Abstract
The production of bio-based succinic acid through microbial CO2 fixation and conversion has gained significant attention as a promising approach to mitigate greenhouse gas emissions. However, the low CO2 utilization efficiency limits the efficient biosynthesis of succinic acid. Therefore, it is [...] Read more.
The production of bio-based succinic acid through microbial CO2 fixation and conversion has gained significant attention as a promising approach to mitigate greenhouse gas emissions. However, the low CO2 utilization efficiency limits the efficient biosynthesis of succinic acid. Therefore, it is crucial from environmental and economic perspectives to enhance the efficiency of CO2 utilization in bio-succinic acid production. This review comprehensively covers the introduction of biosynthetic pathways for microbial CO2 fixation and the conversion of CO2 to succinic acid, as well as the challenges associated with CO2 supply and utilization effectiveness. Moreover, strategies including genetic and metabolic engineering for CO2 fixation, extracellular supply methods of CO2 and some potential technical approaches for CO2 capture (such as micro-nano bubbles, CO2 adsorption material and biofilm) are summarized and presented. Full article
(This article belongs to the Special Issue Feature Review Papers in Fermentation Process Design 2023)
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