Dear Colleagues,

Oxidative stress and associated reactive products have been shown to play a central role in carcinogenesis through the generation of high levels of reactive species capable of attacking lipids, proteins, and DNA. Interconnected modifications of the physiological processes designed to maintain metabolic homeostasis can reduce individual xenobiotic tolerance to oxidative stress and related by-products in susceptible subjects. Subsequently, this can cause over-sensitive reactions to various exogenous and endogenous challenges, resulting in phenotypes characterized by high levels of genomic and other cellular alterations. It is conceivable that such cellular alterations could contribute to a general decline in the physiological mechanisms designed to maintain cellular homeostasis, including DNA damage, mutations, genomic instability, and the disturbance of critical pathways such as transcription and replication.

Molecular epidemiology can play a major role in elucidating the multi-step transformation of normal cells to a malignant state, potentially leading to the definition of predictive biomarkers of cancer risk and carcinogen exposure. In this Special Issue, I invite you to submit reviews and original articles that focus on the link between DNA damage, oxidative stress, and related metabolic by-products in cancer and environmental studies.

You are welcome to read papers in the the previous volumes:

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/DNA-damage

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/DNA_damage_v2

Prof. Dr. Marco E. M. Peluso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• DNA Damage
• Oxidative Stress
• By-Products

• DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies in International Journal of Molecular Sciences (11 articles)
• DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies 2.0 in International Journal of Molecular Sciences (7 articles)