Dear Colleagues,

Chronic kidney disease (CKD) is a health concern that requires prompt attention. The increase in human longevity, together with other important risk factors such as obesity and diabetes, contributes to the global increase in the prevalence of CKD.Aging-related physiological changes may overlap with signs and symptoms of CKD, making diagnosis more complex. Aging is associated with important physiological changes in the renal system, including anatomical (e.g., glomerulosclerosis, vascular hyalinosis and interstitial tubular atrophy) and functional (e.g., decrease in renal plasma flow and in glomerular filtration rate). These modifications make the elderly more prone to meeting the diagnostic criteria for CKD. In addition, age-related diseases (e.g., diabetes and arterial hypertension) may hasten the onset and progression of CKD.This Special Issue aims to cover recent research findings in the following areas: (a) the mechanisms involved in the pathophysiology of CKD related with aging and associated diseases; (b) the changes in traditional and non-traditional disease markers with aging; (c) the mechanistic rational for the use of new therapies in the elderly CKD patient. We cordially invite researchers working in these areas to contribute to this Special Issue with original research or reviews.

Dr. Márcia Carvalho
Dr. Alice Santos-Silva
Dr. Luís Belo
Guest Editors

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• chronic kidney disease
• aging
• age-related diseases
• molecular mechanisms