Advances in the Relationship between Diet, Lipid Metabolism, and Insulin Resistance

Dear Colleagues,

We would like to invite you to submit your manuscripts to this Special Issue entitled “Advances in the Relationship between Diet, Lipid Metabolism, and Insulin Resistance”.

Obesity has become a global health concern considering the epidemic proportions it has reached worldwide and the burden it poses upon health and life span. Indeed, obesity represents a risk factor for a plethora of diseases, including cardiovascular disease, several types of cancer, neurodegenerative disease, and type 2 diabetes mellitus (T2DM). With regard to the latter, obesity fosters insulin resistance which, in turn, is the hallmark of T2DM. Mechanistically, adipocyte overexpansion and dysfunction, due to an increased energy supply, result in lipid spillover from the adipose tissue with the consequent accumulation of fat in tissues not suited for its storage. This phenomenon is called lipotoxicity and represents a key mechanism underpinning the development of insulin resistance. In particular, the intracellular buildup of lipotoxic lipid species such as ceramides and diacylglycerols in metabolically active tissues is able to hamper insulin signal transduction, thereby promoting insulin resistance. In this context, diet quality and energy density are pivotal in promoting body weight gain, adipose tissue dysfunction, and lipotoxicity.

Thus, the aim of this Special Issue is to gather novel insights into the impact of defective lipid metabolism on insulin resistance and whether nutrients, nutraceuticals, and dietary patterns may affect insulin sensitivity by modulating lipid metabolism. As part of this Special Issue, we invite the submission of original manuscripts, as well as meta-analysis, narrative, and systematic reviews, that focus on lipid metabolism in the context of obesity and T2DM. We particularly welcome manuscripts that describe lipidomic studies and provide novel insights into the impact of lipotoxicity on insulin resistance.

Dr. Domenico Sergi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• insulin resistance
• lipotoxicity
• lipid metabolism
• type 2 diabetes mellitus
• dietary lipids
• lipidomics