Dear Colleagues,

Glioblastoma remains the most common and aggressive malignant primary brain tumour. Despite several therapeutic advances and broader understanding towards the complex interplay of glioblastoma genome and epigenome, as well as host immune system, the survival improvement in GBM patients appear to have reached a plateau, and relapses continue to be the biggest clinical challenge.

In this Special Issue, experts in the field will review the current diagnostic, therapeutic and experimental models in GBM. Of interest are research articles (in vivo, in vitro) that may help to further refine the understanding of tumour heterogeneity/microenvironment, the diverse molecular signature in GBM subtypes (epigenome, immune landscape, dysregulation of phylogenetically conserved signalling pathways, etc.) and the relative contribution of glioma stem cells (GSCs). In addition, review articles highlighting new findings in the above areas and underlining the similarities or cross-comparisons between GBM and other human cancers are also welcome. In the prospective articles, manuscripts that address the key challenges in paediatric glioblastoma that need to be considered when applying treatment strategies purely based on adult glioblastoma trials, and the negative results while pursuing a strong scientific hypothesis in GBM, will be of interest.

This special issue is supervised by Dr. Jaroslaw MacIaczyk and Dr. Hugo Guerrero‐Cazares and assisted by our Topical Advisory Panel Member Dr. Amit Sharma (University of Bonn).

Dr. Jaroslaw MacIaczyk
Dr. Hugo Guerrero‐Cazares
Guest Editors

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• glioblastoma
• glioma stem cells
• signalling pathways
• epigenomics
• tumour heterogeneity
• tumour microenvironment