Genetic and Epigenetic Insights into Exosomal Endocrinology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 270
Special Issue Editors
2. University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece
3. Computer Science Department, Natural and Mathematical Sciences, King’ s College London, London, UK
Interests: genetics; epigenetics; exosomes; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; epigenetics; exosomes; endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Exosomes are small membrane-bound vesicles that are secreted by various cells, including endocrine cells. They play crucial roles in intercellular communication by transferring various bioactive molecules, such as proteins, nucleic acids, and lipids, between cells. Exosomes carry genetic and epigenetic information, which may impact multiple cell functions and contribute to the regulation of hormonal signaling pathways. From the genetics and epigenetics perspectives, exosomes contain genetic material, including DNA, mRNAs, lncRNAs, microRNAs, and, possibly, other types of RNAs, transferring information horizontally among cells, organs and tissues On the other hand, exosomes may be involved in epigenetic modifications, such as nucleic acid methylation, histone acetylation, etc.; play crucial roles in gene regulation; and be inherited vertically along consecutive generations. Thus, exosomal cargo may influence both the genetic and epigenetic landscape of recipient cells and modulate many functions of proximal or distal tissues. In addition, given their presence in maternal milk, they may transfer information from mother to infant. Overall, the genetic, epigenetic, and other information carried by exosomes is expected to provide insights into their roles in intercellular communication, as well as in autocrine, paracrine and endocrine regulation.
Prof. Dr. Dimitrios Vlachakis
Prof. Dr. George P. Chrousos
Guest Editors
Manuscript Submission Information
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Keywords
- exosomes
- extracellular vesicles
- cell–cell communication
- endocrinology
