Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Emerging Topics in Ferroptosis
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Emerging Topics in Ferroptosis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 8816

Special Issue Editors

Dr. Sebastian Doll

E-Mail Website
Guest Editor
Institute of Metabolism and Cell Death, Helmholtz Zentrum München, D-85764 Neuherberg, Germany
Interests: ferroptosis in physiology and disease; strategies to inhibit ferroptosis; lipid peroxidation; membrane organization; lipidomics; degenerative diseases
Dr. Maceler Aldrovandi

E-Mail Website
Guest Editor
Institute of Metabolism and Cell Death, Helmholtz Zentrum München, D-85764 Neuherberg, Germany
Interests: ferroptosis; cell death; oxidative stress; redox lipidomics; epilipidomics; lipid metabolism

Special Issue Information

Dear Colleagues,

Ferroptosis is an iron-dependent form of regulated necrotic cell death characterized by a deleterious accumulation of lipid peroxidation. The unique molecular signature of ferroptosis has recently been identified in the context of many (neuro)degenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s disease) and pathophysiological conditions such as ischaemia reperfusion injuries, indicating a so far unused therapeutic potential to inhibit ferroptosis in these conditions. Yet, there are currently no treatment options available in the clinics, which necessitates the development of effective compounds or strategies to mitigate ferroptosis in vivo. At the same time, lipid peroxidation, the driving force of ferroptosis, is poorly understood in biological systems. For decades, the process has been studied in highly controllable ex vivo environments, while understanding its effects on the complex lipid composition and structure of cell membranes is still challenging. A variety of molecular probes are available or in development to visualize changes in membrane organization and even lipid–lipid-phase separations, but their application in the context of ferroptosis has yet to be demonstrated.

For the Special Issue "Emerging Topics in Ferroptosis", we welcome your contributions in the form of original research and review articles on all aspects of ferroptosis and its inhibition in physiological and pathophysiological contexts, as well as articles examining changes in membrane and lipid organization during ferroptosis.

Dr. Sebastian Doll
Dr. Maceler Aldrovandi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ferroptosis in physiology and disease
  • strategies to inhibit ferroptosis
  • lipid peroxidation
  • membrane organization
  • lipidomics
  • degenerative diseases

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

17 pages, 1451 KiB  
Review
Regulation of Ferroptosis in Lung Adenocarcinoma
by Xiangyun Wei, Xiaohe Li, Shuming Hu, Jinke Cheng and Rong Cai
Int. J. Mol. Sci. 2023, 24(19), 14614; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241914614 - 27 Sep 2023
Cited by 2 | Viewed by 1653
Abstract
Lung adenocarcinoma (LUAD) is the most common lung cancer, which accounts for about 35–40% of all lung cancer patients. Despite therapeutic advancements in recent years, the overall survival time of LUAD patients still remains poor, especially KRAS mutant LUAD. Therefore, it is necessary [...] Read more.
Lung adenocarcinoma (LUAD) is the most common lung cancer, which accounts for about 35–40% of all lung cancer patients. Despite therapeutic advancements in recent years, the overall survival time of LUAD patients still remains poor, especially KRAS mutant LUAD. Therefore, it is necessary to further explore novel targets and drugs to improve the prognos is for LUAD. Ferroptosis, an iron-dependent regulated cell death (RCD) caused by lipid peroxidation, has attracted much attention recently as an alternative target for apoptosis in LUAD therapy. Ferroptosis has been found to be closely related to LUAD at every stage, including initiation, proliferation, and progression. In this review, we will provide a comprehensive overview of ferroptosis mechanisms, its regulation in LUAD, and the application of targeting ferroptosis for LUAD therapy. Full article
(This article belongs to the Special Issue Emerging Topics in Ferroptosis)
►▼ Show Figures

Figure 1

24 pages, 1780 KiB  
Review
Ferroptosis in Haematological Malignancies and Associated Therapeutic Nanotechnologies
by Rachel L. Mynott, Ali Habib, Oliver G. Best and Craig T. Wallington-Gates
Int. J. Mol. Sci. 2023, 24(8), 7661; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24087661 - 21 Apr 2023
Cited by 5 | Viewed by 4058
Abstract
Haematological malignancies are heterogeneous groups of cancers of the bone marrow, blood or lymph nodes, and while therapeutic advances have greatly improved the lifespan and quality of life of those afflicted, many of these cancers remain incurable. The iron-dependent, lipid oxidation-mediated form of [...] Read more.
Haematological malignancies are heterogeneous groups of cancers of the bone marrow, blood or lymph nodes, and while therapeutic advances have greatly improved the lifespan and quality of life of those afflicted, many of these cancers remain incurable. The iron-dependent, lipid oxidation-mediated form of cell death, ferroptosis, has emerged as a promising pathway to induce cancer cell death, particularly in those malignancies that are resistant to traditional apoptosis-inducing therapies. Although promising findings have been published in several solid and haematological malignancies, the major drawbacks of ferroptosis-inducing therapies are efficient drug delivery and toxicities to healthy tissue. The development of tumour-targeting and precision medicines, particularly when combined with nanotechnologies, holds potential as a way in which to overcome these obstacles and progress ferroptosis-inducing therapies into the clinic. Here, we review the current state-of-play of ferroptosis in haematological malignancies as well as encouraging discoveries in the field of ferroptosis nanotechnologies. While the research into ferroptosis nanotechnologies in haematological malignancies is limited, its pre-clinical success in solid tumours suggests this is a very feasible therapeutic approach to treat blood cancers such as multiple myeloma, lymphoma and leukaemia. Full article
(This article belongs to the Special Issue Emerging Topics in Ferroptosis)
►▼ Show Figures

Figure 1

24 pages, 1100 KiB  
Review
Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings
by Adrian Bartos and Joanna Sikora
Int. J. Mol. Sci. 2023, 24(4), 3634; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24043634 - 11 Feb 2023
Cited by 2 | Viewed by 2340
Abstract
Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or [...] Read more.
Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively. Full article
(This article belongs to the Special Issue Emerging Topics in Ferroptosis)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop