Osteoarthritis Biomarkers, Diagnosis and Treatments

Dear Colleagues,

For several decades, osteoarthritis (OA) has remained the most common cause of disability in older adults. To date, clinicians face often difficulties assisting their patients as no registered disease-modifying OA drugs exist, and only symptomatic treatments are available. In fact, multiple joint tissues are involved in OA pathophysiology; cartilage was often the focus of research and long thought to play a primary role. However, although cartilage is usually impaired, it is an aneural tissue and pain would be more related to synovium and subchondral bones.

The relationship between osteoarthritis, cartilage degeneration and bone is strong and complex. Research on the mechanisms of osteoarthritis can help us to determine the molecular biology, biochemical, and biomechanical mechanisms involved in the degeneration, repair and regeneration of joints. New targets and compounds for these targets are currently under investigation.

This Special Issue aims to focus on the most recent research conducted in the domain of molecular mechanisms that impact OA repair and treatments. Experimental studies, as well as clinical submissions with biomolecular experiments, are within the scope of our Special Issue and are welcomed for submission, in particular (1) disease-modifying OA drugs, (2) advanced cell treatments for osteoarthritis, (3) changes in cells’ biological mechanisms resulting from osteoarthritis; (4) osteoarthritis and chemical and biomolecular engineering.

All authors are invited to send their research related to the topic of our Special Issue, including both original and review articles, to be assessed and included in the peer review process of our journal.

Dr. Hechmi Toumi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• osteoarthritis
• degenerative joint disease
• biomarkers
• diagnosis
• treatments