International Journal of Molecular Sciences

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Special Issue Editor

Special Issue Information

Dear Colleagues,

Genetic susceptibility refers to the tendency of different populations and individuals to be susceptible to polygenic diseases, such as tumors, under the influence of the external environment, and due to the presence of different genetic structures. Some environmental factors and personal living habits can affect tumor development. All environmental factors that alter cell cycle gene expression, apoptosis, and DNA damage repair are tumor-induced risk factors, including food, natural and artificial radiation, chemicals, and viruses.

This journal welcomes the publication of all findings pertaining to molecular susceptibility in human disease. Pure clinical studies are not within the scope of this Special Issue; however, clinical submissions with biomolecular experiments are welcome.

Dr. Roberto Madeddu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Review

17 pages, 3016 KiB

Open AccessReview

Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men’s Health

by Itzae Adonai Gutiérrez-Hurtado, Astrid Desireé Sánchez-Méndez, Denisse Stephania Becerra-Loaiza, Héctor Rangel-Villalobos, Norma Torres-Carrillo, Martha Patricia Gallegos-Arreola and José Alonso Aguilar-Velázquez

Int. J. Mol. Sci. 2024, 25(8), 4230; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25084230 - 11 Apr 2024

Viewed by 485

Abstract

Until a few years ago, it was believed that the gradual mosaic loss of the Y chromosome (mLOY) was a normal age-related process. However, it is now known that mLOY is associated with a wide variety of pathologies in men, such as cardiovascular diseases, neurodegenerative disorders, and many types of cancer. Nevertheless, the mechanisms that generate mLOY in men have not been studied so far. This task is of great importance because it will allow focusing on possible methods of prophylaxis or therapy for diseases associated with mLOY. On the other hand, it would allow better understanding of mLOY as a possible marker for inferring the age of male samples in cases of human identification. Due to the above, in this work, a comprehensive review of the literature was conducted, presenting the most relevant information on the possible molecular mechanisms by which mLOY is generated, as well as its implications for men’s health and its possible use as a marker to infer age. Full article

(This article belongs to the Special Issue Genetic and Molecular Susceptibility in Human Diseases: 2nd Edition)

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