Modulation of Protein Structure and Function by Lipids: 2nd Edition

Dear Colleagues,

Since the introduction of the fluid mosaic model of cell membrane structure by Singer and Nicolson in 1972, our understanding of the roles of lipids in cellular functions has evolved significantly. Through insights gained with advances in technology, it has become clear that lipids are not merely passive entities that diffuse freely within membrane bilayers; rather, they are also key players in the modulation of protein function. Lipids such as phosphoinositides, sterols, and fatty acids have been shown to affect the function of a growing number of proteins (e.g., G protein-coupled receptors, ion channels, transporters, etc.). Lipids exert their effect on proteins through a variety of mechanisms, such as by modulating protein structure, function, and dynamics; promoting protein oligomerization; and mediating protein–protein interactions in the membrane. As a result, lipids have emerged as central players in diverse disease processes and, hence, in drug development, where lipid-regulated proteins are potential drug targets.

This Special Issue builds upon the foundations of a previous Special Issue, “Modulation of Protein Structure and Function by Lipids”, published in 2022–2023. The preceding Special Issue featured a diverse array of manuscripts, offering a rich tapestry of research and intriguing findings. With the second edition, the aim remains to continue presenting new developments in this field and provide an overview of the current understanding of the impact of lipids on protein structure and function. Both original papers and reviews on this topic are welcome.

Dr. Avia Rosenhouse-Dantsker
Guest Editor

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• protein modulation by lipids
• phosphoinositides
• cholesterol
• sterols
• fatty acids
• G protein-coupled receptors
• ion channels
• transporters

• Modulation of Protein Structure and Function by Lipids in International Journal of Molecular Sciences (8 articles)