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Special Issue "Arrestins: Structure, Function, and Biology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Vsevolod V. Gurevich
E-Mail Website
Guest Editor
Vanderbilt Brain Institute, Vanderbilt University, 2200 Pierce Avenue, Preston Research Building, Rm 417D, Nashville, TN 37232, USA
Interests: arrestin proteins; structure-function; protein engineering; GPCR signaling; GPCR trafficking; receptor regulation; cell proliferation; apoptosis; MAP kinases
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Special Issue Information

Dear Colleagues,

An important challenge in biology is to understand how the information flow in numerous interconnected signalling pathways translates into a coherent cell behaviour. Cell signalling is largely regulated by protein–protein interactions, which are notoriously difficult to target with small molecules. Arrestins are a family of average-sized proteins with 3–5 members in all animals. Arrestins function as versatile adaptors, regulating the signalling by most G-protein-coupled receptors (GPCRs), of which humans express more than 800 subtypes, protein kinases, ubiquitin ligases, and other pathways, as well as GPCR trafficking. Arrestins play a role in the regulation of critical biological processes, including the function of the cardiovascular system, airways, metabolism, behaviour, the action of hormones, neurotransmitters, etc. Available structural information has revealed the role of individual arrestin elements in GPCR binding, some of which determine the receptor preference of arrestin proteins, and in arrestin transition from basal into “active” receptor-bound-like conformation. However, the identification of arrestin elements involved in their interactions with non-receptor partners, which serve as effectors in arrestin-mediated signalling, is lagging far behind. This information is vital for the design of signalling-biased arrestins that can channel the signalling of particular GPCRs to desirable pathways or away from undesirable ones.

Prof. Dr. Vsevolod V. Gurevich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Arrestin
  • GPCR
  • Cell signalling
  • Receptor trafficking
  • Protein multifunctionality
  • Vision
  • Protein kinase
  • Structure–function
  • Protein engineering
  • Signalling bias

Published Papers

This special issue is now open for submission.
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