Cellular Signalling in Cell Fusion 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3529
Special Issue Editor
Interests: cell fusion; breast cancer; stem cells; macrophages; inflammation; metastasis; drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The biological phenomenon of cell fusion remains a mystery. Even though it is mandatory for several physiological and pathophysiological processes, little is known about it. Cell fusion is a tightly regulated process since cells are not fusogenic per se. They first have to be converted to a pro-fusogenic state in order to be able to hybridize. Subsequently, they have to assume a non-fusogenic state once again.
Some questions remain. Which signals and signal pathways are necessary for cells to assume a pro-fusogenic state, and what does a pro-fusogenic state look like?
How do pro-fusogenic cells recognize their fusion partners and which proteins/mechanisms are involved? How is the cell fusion process ultimately terminated?
Which phenotype do hybrid cells adopt?
Do they remain at a multi-nuclear stage or does heterokaryon-to-synkaryon transition occur, which may be associated with aneuploidy?
These questions will be answered in this Special Issue.
Prof. Dr. Thomas Dittmar
Guest Editor
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Keywords
- cell fusion
- signal transduction
- aneuploidy
- cancer
