Special Issue "Cell Therapy Approaches for Diabetes"
Deadline for manuscript submissions: 31 December 2021.
Interests: stem cells; amniotic membrane; mesenchymal stem cells; Wharton jelly; beta cell differentiation; immunomodulation
Pancreatic islet beta cells are endocrine cells producing the hormone insulin that control the metabolism of glucose.
An autoimmune attack can cause a loss of beta cells, leading to a disease termed type 1 diabetes (T1D). Treatment with exogenous insulin is a life-saving intervention, but it can cause serious adverse effects. Over time, severe complications can arise in T1D patients. Frequently, these complications cannot be managed effectively. Since the discovery of insulin, many steps have been taken towards a safer and more effective treatment for T1D. Transplantation of cadaveric pancreas and isolated islets showed that beta cell replacement can treat T1D and prevents complications very effectively, but both strategies have important limitations.
Regenerative medicine and stem cell therapy may represent the solution for the treatment of non-curable human diseases such as T1D. Certain types of stem and progenitor cells can be harnessed to generate insulin-producing cells for beta-cell replenishment. Other types of stem/progenitor cells can be utilized to inhibit autoimmune mechanisms and the rejection of transplanted beta-cell. Moreover, some of them can exert trophic effects on beta cells. In this Special Issue, multiple stem and progenitor cells can be investigated to better define their potential as cell therapies for T1D.
Dr. Laura Bonsi
Manuscript Submission Information
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- pancreatic differentiation
- stem cells
- mesenchymal stem (stromal) cells
- pancreatic islets