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Special Issue "Cell Therapy Approaches for Diabetes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Laura Bonsi
E-Mail Website
Guest Editor
Department of Experimental, Diascostic and Specialty Medicine o.p. Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
Interests: stem cells; amniotic membrane; mesenchymal stem cells; Wharton jelly; beta cell differentiation; immunomodulation

Special Issue Information

Dear Colleagues,

Pancreatic islet beta cells are endocrine cells producing the hormone insulin that control the metabolism of glucose.

An autoimmune attack can cause a loss of beta cells, leading to a disease termed type 1 diabetes (T1D). Treatment with exogenous insulin is a life-saving intervention, but it can cause serious adverse effects. Over time, severe complications can arise in T1D patients. Frequently, these complications cannot be managed effectively. Since the discovery of insulin, many steps have been taken towards a safer and more effective treatment for T1D. Transplantation of cadaveric pancreas and isolated islets showed that beta cell replacement can treat T1D and prevents complications very effectively, but both strategies have important limitations.

Regenerative medicine and stem cell therapy may represent the solution for the treatment of non-curable human diseases such as T1D. Certain types of stem and progenitor cells can be harnessed to generate insulin-producing cells for beta-cell replenishment. Other types of stem/progenitor cells can be utilized to inhibit autoimmune mechanisms and the rejection of transplanted beta-cell. Moreover, some of them can exert trophic effects on beta cells. In this Special Issue, multiple stem and progenitor cells can be investigated to better define their potential as cell therapies for T1D.

Dr. Laura Bonsi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pancreatic differentiation
  • stem cells
  • diabetes
  • mesenchymal stem (stromal) cells
  • pancreatic islets

Published Papers

This special issue is now open for submission.
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