Cholinergic Signaling in Human Health and Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 March 2022) | Viewed by 2559
Special Issue Editor
Interests: intestinal organoid; stem cell; signaling; non-neuronal acetylcholine; acetylcholine receptor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous Special Issue "Cholinergic Signaling in Human Health and Diseases".
It is now well-established that acetylcholine (ACh) and its receptors (nicotinic and muscarinic receptors (n- and mAChRs)) as important constituents of the cholinergic system are ubiquitous molecules in life. Other components of the cholinergic system (choline acetyltransferase (ChAT), choline transporter (ChT), and acetylcholinesterase (AChE)) have also been demonstrated in mammalian non-neuronal cells, including those of humans. The traditional view of ACh regards it as a neurotransmitter. In addition to neurotransmission, ACh plays important roles in various aspects of cell biology and homeostasis outside of the nervous system. ACh is actually synthesized by all live cells and plays an intermediary role in the interactions of non-neuronal cells with the external environment, endocrine hormones, growth factors, cytokines, and the central nervous system. Thus, cholinergic signaling in non-neuronal cells is comparable to neuronal cholinergic signaling. In addition to improving our understanding of the structure and function of the cholinergic system, significant progress has also been made in elucidating the roles of neuronal and non-neuronal ACh in the pathogenesis and treatment of human disease. This Issue will explore new insights into how cholinergic signaling functions in mammals, how its roles contribute to protecting the body from disease, and how the molecules can be manipulated to treat disease.
Dr. Toshio Takahashi
Guest Editor
Manuscript Submission Information
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Keywords
- neuron
- immune cell
- stem cell
- signaling
- acetylcholine (ACh)
- non-neuronal ACh
- acetylcholine receptor
- acetylcholine receptor to muscarinic ACh receptor
- nicotinic ACh receptor
