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Special Issue "Cholinergic Signaling in Human Health and Diseases 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 October 2021.

Special Issue Editor

Dr. Toshio Takahashi
E-Mail Website
Guest Editor
Suntory Foundation for Life Sciences, Bioorganic Research Institute, Kyoto, Japan
Interests: intestinal organoid; stem cell; signaling; non-neuronal acetylcholine; acetylcholine receptor
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue "Cholinergic Signaling in Human Health and Diseases".

It is now well-established that acetylcholine (ACh) and its receptors (nicotinic and muscarinic receptors (n- and mAChRs)) as important constituents of the cholinergic system are ubiquitous molecules in life. Other components of the cholinergic system (choline acetyltransferase (ChAT), choline transporter (ChT), and acetylcholinesterase (AChE)) have also been demonstrated in mammalian non-neuronal cells, including those of humans. The traditional view of ACh regards it as a neurotransmitter. In addition to neurotransmission, ACh plays important roles in various aspects of cell biology and homeostasis outside of the nervous system. ACh is actually synthesized by all live cells and plays an intermediary role in the interactions of non-neuronal cells with the external environment, endocrine hormones, growth factors, cytokines, and the central nervous system. Thus, cholinergic signaling in non-neuronal cells is comparable to neuronal cholinergic signaling. In addition to improving our understanding of the structure and function of the cholinergic system, significant progress has also been made in elucidating the roles of neuronal and non-neuronal ACh in the pathogenesis and treatment of human disease. This Issue will explore new insights into how cholinergic signaling functions in mammals, how its roles contribute to protecting the body from disease, and how the molecules can be manipulated to treat disease.

Dr. Toshio Takahashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neuron
  • immune cell
  • stem cell
  • signaling
  • acetylcholine (ACh)
  • non-neuronal ACh
  • acetylcholine receptor
  • acetylcholine receptor to muscarinic ACh receptor
  • nicotinic ACh receptor

Published Papers

This special issue is now open for submission.
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