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Special Issue "Effects of Environmental Factors on the Nervous Tissue Functioning: Molecular Bases of Neuropathogenic Mechanisms"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Grégory Pourié
E-Mail Website
Guest Editor
Université de Lorraine, Nancy, France
Interests: receptors; signal transduction; cellular pathways; functional plasticity; synapse dynamic; behaviors; neuronal and glial metabolism; cerebral pathologies

Special Issue Information

Dear Colleagues,

The central nervous system (CNS) is one of the organs that must be above all preserved in order to avoid dramatic outcome. The blood brain barrier (BBB) plays a critical role for brain protection. Nevertheless, brain tissue mostly represents a mosaic of different sub-regions rather than a real organ and as a consequence can react in various ways to pathogenic effects despite the role of the BBB. Comparing with other organs, the scientific knowledge concerning CNS is very recent and numerous cellular and molecular mechanisms in nervous circuits are still unclear especially in case of environmental influence. Beside the CNS, peripheric nerves are also subjected to external factors. Among factors that putatively modulate neuronal functions, environmental factors represent a large family of compounds crossing the BBB and influencing both neurons and glial cells dynamics. Thus, since a few decades, pollutants and nutritional imbalance are increasing with dramatic consequences on gene expression, signal transduction, molecular pathways, metabolism and synaptic functioning. Recent findings have highlighted the impact of various environmental factors on neurodegenerative pathologies and psychiatric disorders. The elucidation of molecular mechanisms involved in such deregulations of nervous tissues could lead to propose therapeutic targets for unsolved current nervous dysfunctions.

This special issue encourages the submission of original research articles, short communications or reviews related to the above presented topics. In particular, studies concerning the functioning of either neurons and glial cells in terms of genes expression, molecular pathways, external signals reception and molecular basis of behaviors, under the influence of pollutants or nutritional factors, are welcome.

Dr. Grégory Pourié
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • environmental factors
  • toxicology
  • nutrition
  • brain
  • peripheric nerves
  • neuron-glia crosstalk
  • molecular actors

Published Papers (1 paper)

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Open AccessArticle
Effects of Irregular Feeding on the Daily Fluctuations in mRNA Expression of the Neurosecretory Protein GL and Neurosecretory Protein GM Genes in the Mouse Hypothalamus
Int. J. Mol. Sci. 2021, 22(4), 2109; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22042109 - 20 Feb 2021
Viewed by 408
Circadian desynchrony induced by a long period of irregular feeding leads to metabolic diseases, such as obesity and diabetes mellitus. The recently identified neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM) are hypothalamic small proteins that stimulate food intake and fat accumulation [...] Read more.
Circadian desynchrony induced by a long period of irregular feeding leads to metabolic diseases, such as obesity and diabetes mellitus. The recently identified neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM) are hypothalamic small proteins that stimulate food intake and fat accumulation in several animals. To clarify the mechanisms that evoke feeding behavior and induce energy metabolism at the appropriate times in accordance with a circadian rhythm, diurnal fluctuations in Npgl and Npgm mRNA expression were investigated in mice. Quantitative RT-PCR analysis revealed that the mRNAs of these two genes were highly expressed in the mediobasal hypothalamus during the active dark phase under ad libitum feeding. In mice restricted to 3 h of feeding during the inactive light phase, the Npgl mRNA level was augmented in the moment prior to the feeding period and the midnight peak of Npgm mRNA was attenuated. Moreover, the mRNA expression levels of clock genes, feeding regulatory neuropeptides, and lipid metabolic enzymes in the central and peripheral tissues were comparable to those of central Npgl and Npgm. These data suggest that Npgl and Npgm transcription fluctuates daily and likely mediates feeding behavior and/or energy metabolism at an appropriate time according to the meal timing. Full article
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