Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue, “Molecular Regulation of the Endomembrane System”.

One striking observation in eukaryotic cells is that over time, their organelles maintain a remarkably constant size and shape despite high levels of biochemical activity. In the early secretory pathway, for example, proteins synthesized in the endoplasmic reticulum (ER) but which are destined for secretion are constantly packaged into membrane transport carriers that leave the ER and are directed towards the Golgi complex. The fact that the ER maintains its overall size, shape, and volume tells us that this organelle must receive—from the Golgi complex—an equivalent amount of membrane per unit time. Indeed, if all the organelles in the endomembrane system are to retain their functionality, such counterbalancing of the membrane flow must exist between all compartments that communicate with each other. This control of the endomembrane system is achieved through a variety of factors, including the activity of proteins and lipids resident in each compartment, as well as through long-range signaling events across the cell and linkage to the cytoskeleton. What is also clear is that perturbation of transport pathways between organelles, manifested in a number of diseases, results in aberrant organelle function and morphology.

In this Special Issue entitled “Molecular Regulation of the Endomembrane System 2.0”, we are seeking novel research or review articles highlighting the variety of machinery and regulatory mechanisms used in membrane traffic, with specific regard to how membrane flux is controlled and how it determines the identity and function of organelles. Also relevant is how dysfunctional trafficking events have implications in disease. We are open to articles addressing the molecular control of membrane traffic in a variety of model systems. We look forward to receiving your contributions to this exciting Special Issue.

Dr. Jeremy Simpson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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• membrane traffic
• secretory pathway
• endocytic pathway
• organelle identity
• coat proteins
• small GTPases
• lipids and phosphoinositides
• endoplasmic reticulum
• Golgi complex endosomal system
• cytoskeleton
• signalling pathways
• disease, infection, and membrane traffic