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Special Issue "The Endosomal-Lysosomal System: A Dynamic Network of Molecular and Cellular Pathways"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Dr. Anna Onnis
E-Mail Website
Guest Editor
Department of Life Science, University of Siena, Siena, Italy
Interests: vesicular trafficking; immune synapse; T- and B- lymphocytes
Dr. Francesca Finetti
E-Mail Website1 Website2
Guest Editor
Department of Life Sciences, University of Siena, Siena, Italy
Interests: vesicular trafficking; intraflagellar transport; autophagy; lysosomes; immunological synapse; T and B lymphocytes

Special Issue Information

Dear Colleagues,

The endosomal-lysosomal system is a highly dynamic network of intracellular membranous compartments where different trafficking pathways converge to regulate the delivery and localization of cargo molecules as well as their processing. The active transport through these compartments is based on endocytosis and exocytosis and exploits the tight coordination of several molecular mechanisms to control both endosome processing and cargo sorting. The endosomal-lysosomal system is essential for cell physiology and is involved in maintaining cellular homeostasis and supporting organism development and growth. Accordingly, defective endosomal trafficking is considered to be a pathogenic factor in a number of diseases, including metabolic and neurodegenerative disorders, immune diseases and cancer. 

This Special Issue aims to cover research dissecting the molecular and cellular mechanisms involved in the formation and maturation of endosomes/lysosomes, vesicle trafficking, protein sorting and targeted degradation of specific cargoes. We will explore the role of endosomal/lysosomal system in health and disease and address how this system may be targeted for therapeutic purposes.

Dr. Anna Onnis
Dr. Francesca Finetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • endosomes
  • lysosomes
  • vesicular trafficking
  • endocytosis
  • exocytosis
  • protein sorting
  • cargo degradation

Published Papers

This special issue is now open for submission.
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