Dear Colleagues,

Extracellular vesicles (EVs) are circulating vehicles carrying various bioactive molecules, including microRNA, mRNA, protein, and DNA. So far, EVs have been classified into three major classes: exosomes (endosome origin), shed-microvesicles (plasma membrane origin), and apoptotic bodies, based on mainly their sizes and surface molecules. Recent studies on the roles of EVs have unveiled their crucial roles in intercellular communication in the tumor microenvironment. However, many factors still remain undefined. For example, their isolation and classification methods are still developing. How their cargo is sorted and/or how their destination is determined are not elucidated. Understanding fundamental EV biology is critical to utilizing them as therapeutic carriers in the future. This Special Issue kindly requests deeper advanced studies on the roles of EVs associated with their properties in the tumor microenvironment.

Dr. Nami O. Yamada
Guest Editor

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• Cancer
• Shed-microvesicles
• Exosomes
• Extracellular vesicles
• Tumor microenvironment
• Cell-to-cell communication