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Focal Therapy and Oncology: State of Play in 2021

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 5930

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue, “Focal therapy and oncology: state of play in 2021”, will cover a selection of recent research topics and current review articles related to the intracellular signaling of resistance to apoptosis in cancer. Up-to-date review articles, commentaries and experimental papers are all welcome.

Despite medical research advances in anti-cancer treatments, many side effects persist in patients, as well as development of resistances to conventional treatments. The development of new anti-cancer therapeutic strategies is necessary in order to improve care of patients. Focal therapies, such as photodynamic therapy using photosensitizers, come as an innovative therapeutic strategy that severely restricts these undesirable side effects. Photodynamic therapy has been approved for the treatment of some cancers due to the generation of cytotoxic reactive oxygen species only with photoactivated photosensitizers.

It has been shown that cancer cells escape the apoptotic phenomenon, allowing them to grow uncontrollably. Apoptosis in anti-cancer PDT is mostly induced by its intrinsic pathway. The apoptotic process is subject to numerous regulations that can lead to resistance mechanisms. These resistances are often responsible for the ineffectiveness of certain anti-cancer therapies, underlining the growing interest in interest in combination therapies.

Prof. Dr. Bertrand Liagre
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • apoptosis
  • focal therapy
  • new treatment
  • clinical trials

Published Papers (1 paper)

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Review

28 pages, 8234 KiB  
Review
Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction
by Karina J. Lagos, Hilde H. Buzzá, Vanderlei S. Bagnato and María Paulina Romero
Int. J. Mol. Sci. 2022, 23(1), 22; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23010022 - 21 Dec 2021
Cited by 93 | Viewed by 5391
Abstract
Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and [...] Read more.
Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of therapeutic materials against cancer. This review summarizes the progress made in recent years regarding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced antitumor action by improving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies. Full article
(This article belongs to the Special Issue Focal Therapy and Oncology: State of Play in 2021)
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