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Special Issue "Genetics and Genomics of Vector-Borne Disease Pathogens"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Prof. Dr. Eugenia Lo
E-Mail Website
Guest Editor
Biological Sciences, University of North Carolina Charlotte, Charlotte, NC 28262, USA
Interests: malaria parasites; spatial epidemiology; host-pathogen interactions; invasion mechanism; population genomics; transcriptomics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. In 2018, the World Health Organization estimated 3.4 billion people were at risk of malaria with approximately 93% of malaria cases and 94% of deaths occurring in sub-Saharan Africa. In non-human primates, approximately 25 malaria parasite species have been described (Faust and Dobson 2015, One Health 1:66-75). Among them, six species including Plasmodium falciparum, P. vivax. P. malariae, P. ovale, P. knowlesi and P. simium are known to infect humans, causing symptoms. Plasmodium falciparum is responsible for hundreds of millions of cases of malaria and kills about half a million annually. While P. falciparum causes most malaria mortality, P. vivax can also cause severe disease in South America and South East Asia. Recently, there has also been a surge of P. vivax in sub-Saharan Africa.

Knowledge around the genetics and genomics of malaria parasites can uncover inheritance patterns and mutational changes of infectious pathogens, molecular mechanisms underlying red blood cell invasion, as well as effectiveness of malaria interventions over time. The advent and accessibility of high-throughput sequencing technologies and bioinformatic tools in the last decade provides remarkable insights into the global genetic structure, genomic composition and recombination rates, as well as genetic variants associated with antimalarial drug resistance of Plasmodium. Global malaria elimination programs focus primarily on P. falciparum. Nevertheless, non-P. falciparum malaria still presents a major challenge for malaria elimination. Recent research efforts and control programs have drawn resources to P. vivax malaria. By contrast, other Plasmodium species receive little attention, and malaria caused by these organisms is among the most neglected tropical diseases.

This Special Issue will cover the genetic and/or genomic features of the various malaria parasite species in the context of disease epidemiology, evolution, functions of genes or gene products, and host–pathogen interactions. We cordially invite researchers working in these areas to contribute to this Special Issue with original research or reviews.

Prof. Eugenia Lo
Dr. Karthigayan Gunalan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • functional genomics
  • epigenetics
  • molecular parasitology
  • cell biology
  • antimalarial resistance
  • antigenic variations
  • gene functions and products
  • host–pathogen interactions
  • malaria interventions

Published Papers

This special issue is now open for submission.
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