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Special Issue "New Challenges in Human & Animal Vaccines"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Chang Won Choi
E-Mail Website
Guest Editor
Department of Biology & Medicinal Science, Pai Chai University, 155-40 Baejae-ro, Seo-Gu, Daejeon 35345, Korea
Interests: plant-derived biomedicines; plant-made pharmaceuticals; molecular farming; recombinant proteins; plant metabolic engineering; hypoglycaemic; hypolipidemic; antioxidants; antiviral; bacterial ghost vaccine; inactivated vaccine; subunit vaccine
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Special Issue Information

Dear Colleagues,

Vaccines are one of the most powerful and effective healthcare advances ever developed. Nevertheless, the most effective vaccine candidate for an economical price is still lacking for developing-world populations. Several factors limit complete global immunization and among these is the cost of procuring and distributing vaccines in lower-income countries. In this view, the topic focuses on the development of an economical vaccine candidate against infectious diseases for humans and animals for the global public good. Therefore, a new strategy is required to induce a broad range of protective immunity against bacterial, fungal, or viral pathogens. In particular, we need to develop a vaccine technology platform, targeting quality, efficacy, safety, simplicity, cost-effectiveness, and affordability. Possible vaccine candidates include live attenuated vaccines, inactivated vaccines, subunit vaccines, toxoid vaccines, conjugate vaccines, DNA vaccines and recombinant vector vaccines. Recently, researchers worldwide have developed new vaccines against SARS-CoV-2, the virus causing the COVID-19 pandemic. There are two main approaches to designing a vaccine. A vaccine produced by Pfizer or Moderna is made using mRNA, a technology that delivers mRNA instructions for cells to build the surface protein (spike) of SARS-CoV-2. Another vaccine produced by J&J or AstraZenaca is a viral vectored vaccine to instruct human cells to make the SARS-2 spike protein, which then triggers an immune response. A harmless adenovirus has been engineered to carry the genetic code for the SARS-2 spike protein. Once the adenovirus enters cells, they use that code to make spike proteins.

In this Special Issue, possible approaches cover the fundamental discovery of vaccine candidates and their delivery systems through to their preclinical/clinical trials. In addition, the topic includes normal immunologic responses to vaccination, patterns of abnormal responses, and methods for assessing these responses. The immune response should include a general evaluation of the immune system, including measurements of antibody levels and functional assessments of different immune cells, as well as cytokines. I wish to thank all authors for their contributions to this Special Issue.

Prof. Dr. Chang Won Choi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Vaccine candidates
  • Broad range of protective immunity
  • Vaccine technology platform
  • Immune responses
  • Delivery system
  • Discovery, preclinical and clinical trials

Published Papers

This special issue is now open for submission.
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