Special Issue "Extracellular Heat Shock Proteins as Regulator of the Immune System"
Deadline for manuscript submissions: 31 December 2021.
Interests: tissue remodeling in chronic lung diseases; asthma; COPD; lung fibrosis; epi-genetics; cell signaling; cell differentiation; epithelial cells; fibroblasts; airway smooth muscle cells
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Heat shock proteins (HSPs) were first described in 1962 as temperature-sensitive proteins in Drosophila. HSPs have mainly been studied as intracellular proteins, helping other proteins to maintain their structure and function under stress conditions, including physiological stress, mechanical stress, environmental stress (heat, cold, UV-light), and infections. In 1991, it was reported that extracellular HSPs activate gamma-delta T-lymphocytes.
The HSPs of microorganisms such as Chlamydia induce the formation of antibodies to human HSPs, leading to an auto-immune reaction, which is associated with the chronic inflammation observed in rheumatic disorders, cardiovascular diseases and others.
Circulating HSP60 has been linked to increased pro-inflammatory cytokine levels in patients with coronary heart diseases, and obesity. In contrast, circulating HSP70 protected against cardiovascular disease. However, serum HSP70 correlated with chronic glomerulonephritis, and hepatic dysfunction.
The contribution of extracellular HSPs to health and disease is not well understood and requires further investigation. The action of extracellular HSPs is most likely modified by the presence of anti-HSP antibodies, and the ratio between these two factors and their consequences in chronic inflammatory diseases remains incompletely understood.
Therefore, we are collecting manuscripts investigating the function and signal mediation pathways of extracellular HSPs and anti-HSP antibodies in the context of chronic inflammation.
Prof. Dr. Michael Roth
Dr. Fang Lei
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Circulating/extracellular heat shock protein (HSP)
- Chronic inflammation
- Autoimmune diseases
- Chronic inflammatory
- lung diseases (asthma, COPD)
- Cardiovascular diseases