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300 Years of the University of Burgundy, France—Focus on Three Health Research Themes: Neurodegenerative Diseases/Brain Function, Cardiovascular Diseases, and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (29 March 2024) | Viewed by 2385

Special Issue Editor

Dr. Anne Vejux

E-Mail Website
Guest Editor
Team “Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism”, Université de Bourgogne, 21000 Dijon, France
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet, peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the 300th anniversary of the University of Burgundy in France, focusing on three major areas developed in the field of health: neurodegenerative diseases and therefore brain function, cardiovascular diseases, and cancer, celebrating our research teams and their high-quality work.

This Special Issue aims to highlight fundamental, applied, and interdisciplinary research on the wide range of topics studied by the laboratories of the UFR Sciences, Vie, Terre et Environnement, or the UFR Sciences de Santé and their collaborators in the framework of the IJMS journal. Review articles and original research papers are welcome.

Dr. Anne Vejux
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • cardiovascular diseases
  • cell death
  • mitochondria
  • peroxisome
  • lipoproteins
  • inflammation
  • oxidative stress
  • cardiovascular function
  • brain function
  • immunity
  • cancer
  • chemoprevention
  • nutrients
  • antioxidant therapies
  • omega-3 fatty acids

Published Papers (4 papers)

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Research

18 pages, 1470 KiB  
Article
Topology and Dynamics of Transcriptome (Dys)Regulation
by Michel Planat and David Chester
Int. J. Mol. Sci. 2024, 25(9), 4971; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25094971 - 02 May 2024
Viewed by 180
Abstract
RNA transcripts play a crucial role as witnesses of gene expression health. Identifying disruptive short sequences in RNA transcription and regulation is essential for potentially treating diseases. Let us delve into the mathematical intricacies of these sequences. We have previously devised a mathematical [...] Read more.
RNA transcripts play a crucial role as witnesses of gene expression health. Identifying disruptive short sequences in RNA transcription and regulation is essential for potentially treating diseases. Let us delve into the mathematical intricacies of these sequences. We have previously devised a mathematical approach for defining a “healthy” sequence. This sequence is characterized by having at most four distinct nucleotides (denoted as nt≤4). It serves as the generator of a group denoted as fp. The desired properties of this sequence are as follows: fp should be close to a free group of rank nt−1, it must be aperiodic, and fp should not have isolated singularities within its SL2(C) character variety (specifically within the corresponding Groebner basis). Now, let us explore the concept of singularities. There are cubic surfaces associated with the character variety of a four-punctured sphere denoted as S24. When we encounter these singularities, we find ourselves dealing with some algebraic solutions of a dynamical second-order differential (and transcendental) equation known as the Painlevé VI Equation. In certain cases, S24 degenerates, in the sense that two punctures collapse, resulting in a “wild” dynamics governed by the Painlevé equations of an index lower than VI. In our paper, we provide examples of these fascinating mathematical structures within the context of miRNAs. Specifically, we find a clear relationship between decorated character varieties of Painlevé equations and the character variety calculated from the seed of oncomirs. These findings should find many applications including cancer research and the investigation of neurodegenative diseases. Full article
(This article belongs to the Special Issue 300 Years of the University of Burgundy, France—Focus on Three Health Research Themes: Neurodegenerative Diseases/Brain Function, Cardiovascular Diseases, and Cancer)
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14 pages, 1812 KiB  
Article
Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer
by Aditya Shreenivas, Daisuke Nishizaki, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Shumei Kato and Razelle Kurzrock
Int. J. Mol. Sci. 2024, 25(9), 4742; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25094742 - 26 Apr 2024
Viewed by 254
Abstract
ADORA2A (adenosine A2a receptor) and ADORA2B propagate immunoregulatory signals, including restricting both innate and adaptive immunity, though recent data also suggest a tumor suppressor effect in certain settings. We evaluated the RNA expression from 514 tumors in a clinical-grade laboratory; 489 patients with [...] Read more.
ADORA2A (adenosine A2a receptor) and ADORA2B propagate immunoregulatory signals, including restricting both innate and adaptive immunity, though recent data also suggest a tumor suppressor effect in certain settings. We evaluated the RNA expression from 514 tumors in a clinical-grade laboratory; 489 patients with advanced/metastatic disease had clinical outcome correlates. Transcript expression was standardized to internal housekeeping genes and ranked (0–100 scale) relative to 735 specimens from 35 different cancer types. Transcript abundance rank values were defined as “low/moderate” (0–74) or “high” (75–100) percentile RNA expression ranks. Overall, 20.8% of tumors had high ADORA2A (≥75 percentile RNA rank). The greatest proportion of high ADORA2A expressors was found in neuroendocrine and breast cancers and sarcomas, whereas the lowest was found in colorectal and ovarian cancers, albeit with patient-to-patient variability. In multivariable logistic regression analysis, there was a significant positive correlation between high ADORA2A RNA expression and a high expression of the immune checkpoint-related molecules PD-1 (p = 0.015), VISTA (p ≤ 0.001), CD38 (p = 0.031), and CD39 (p ≤ 0.001). In 217 immunotherapy-treated patients, high ADORA2A did not correlate significantly with progression-free (p = 0.51) or overall survival (OS) (p = 0.09) from the initiation of the checkpoint blockade. However, high versus not-high ADORA2A transcript expression correlated with longer OS from the time of advanced/metastatic disease (N = 489 patients; (HR 0.69 (95% CI 0.51–0.95) (p = 0.02)). Therefore, high ADORA2A transcript levels may be a favorable prognostic factor, unrelated to immunotherapy. Importantly, ascertaining co-expression patterns of ADORA2A with PD-1 and VISTA in individual tumors as a basis for the precision co-targeting of ADORA2A and these other checkpoint-related molecules warrants investigation in clinical trials. Full article
(This article belongs to the Special Issue 300 Years of the University of Burgundy, France—Focus on Three Health Research Themes: Neurodegenerative Diseases/Brain Function, Cardiovascular Diseases, and Cancer)
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12 pages, 6708 KiB  
Article
Investigating the Role of Brain Natriuretic Peptide (BNP) and N-Terminal-proBNP in Thrombosis and Acute Ischemic Stroke Etiology
by Rosanna Rossi, Duaa Jabrah, Andrew Douglas, James Prendergast, Abhay Pandit, Michael Gilvarry, Ray McCarthy, Petra Redfors, Annika Nordanstig, Turgut Tatlisumak, Erik Ceder, Dennis Dunker, Jeanette Carlqvist, István Szikora, Georgios Tsivgoulis, Klearchos Psychogios, John Thornton, Alexandros Rentzos, Katarina Jood, Jesus Juega and Karen M. Doyleadd Show full author list remove Hide full author list
Int. J. Mol. Sci. 2024, 25(5), 2999; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25052999 - 05 Mar 2024
Viewed by 760
Abstract
The need for biomarkers for acute ischemic stroke (AIS) to understand the mechanisms implicated in pathological clot formation is critical. The levels of the brain natriuretic peptides known as brain natriuretic peptide (BNP) and NT-proBNP have been shown to be increased in patients [...] Read more.
The need for biomarkers for acute ischemic stroke (AIS) to understand the mechanisms implicated in pathological clot formation is critical. The levels of the brain natriuretic peptides known as brain natriuretic peptide (BNP) and NT-proBNP have been shown to be increased in patients suffering from heart failure and other heart conditions. We measured their expression in AIS clots of cardioembolic (CE) and large artery atherosclerosis (LAA) etiology, evaluating their location inside the clots, aiming to uncover their possible role in thrombosis. We analyzed 80 thrombi from 80 AIS patients in the RESTORE registry of AIS clots, 40 of which were of CE and 40 of LAA etiology. The localization of BNP and NT-BNP, quantified using immunohistochemistry and immunofluorescence, in AIS-associated white blood cell subtypes was also investigated. We found a statistically significant positive correlation between BNP and NT-proBNP expression levels (Spearman’s rho = 0.668 p < 0.0001 *). We did not observe any statistically significant difference between LAA and CE clots in BNP expression (0.66 [0.13–3.54]% vs. 0.53 [0.14–3.07]%, p = 0.923) or in NT-proBNP expression (0.29 [0.11–0.58]% vs. 0.18 [0.05–0.51]%, p = 0.119), although there was a trend of higher NT-proBNP expression in the LAA clots. It was noticeable that BNP was distributed throughout the thrombus and especially within platelet-rich regions. However, NT-proBNP colocalized with neutrophils, macrophages, and T-lymphocytes, suggesting its association with the thrombo-inflammatory process. Full article
(This article belongs to the Special Issue 300 Years of the University of Burgundy, France—Focus on Three Health Research Themes: Neurodegenerative Diseases/Brain Function, Cardiovascular Diseases, and Cancer)
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14 pages, 10343 KiB  
Article
Impaired Expression of Humanin during Adrenocortical Carcinoma
by Małgorzata Blatkiewicz, Marta Szyszka, Anna Olechnowicz, Kacper Kamiński, Karol Jopek, Hanna Komarowska, Marianna Tyczewska, Anna Klimont, Tomasz Wierzbicki, Marek Karczewski, Marek Ruchała and Marcin Rucinski
Int. J. Mol. Sci. 2024, 25(2), 1038; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25021038 - 15 Jan 2024
Viewed by 745
Abstract
The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining [...] Read more.
The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining cell survival and preventing cell death under various conditions. Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy that results from adrenal hormone dysfunction. This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC. For the first time, our study revealed significant reduction in the mRNA expression of humanin in patients with ACC compared to healthy controls. However, no significant changes were observed in the serum humanin levels. Interestingly, we identified a positive correlation between patient age and serum humanin levels and a negative correlation between tumor size and LDL levels. While the impaired expression of humanin in patients with ACC may be attributed to mitochondrial dysfunction, an alternative explanation could be related to diminished mitochondrial copy number. Further investigations are warranted to elucidate the intricate relationship among humanin, mitochondrial function, and ACC pathology. Full article
(This article belongs to the Special Issue 300 Years of the University of Burgundy, France—Focus on Three Health Research Themes: Neurodegenerative Diseases/Brain Function, Cardiovascular Diseases, and Cancer)
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