Special Issue "Iron-Sulfur Clusters and Proteins"
Deadline for manuscript submissions: 31 March 2021.
Interests: mitochondrial (patho)physiology; Friedreich ataxia & frataxin; iron-sulfur proteins; iron-sulfur clusters assembly
Iron–sulfur (FeS) clusters are inorganic cofactors that are essential in several major biochemical processes in prokaryotic and eukaryotic organisms, including catalysis, electron transfer, determining of protein structure, and regulation of gene expression. Different FeS centers may exist in nature, ranging from the simplest [2Fe-2S] and [4Fe-4S] units, found in plant and bacterial ferredoxins, as well as in respiratory complexes I-III of bacteria and mitochondria, to more complex polymetallic clusters characterized in metalloproteins, such as nitrogenase and hydrogenase, involved in nitrogen fixation and hydrogen metabolism respectively. The biosynthesis of FeS clusters and their transfer to the target apoproteins are highly complex and strictly coordinated processes driven by different, phylogenetically unrelated molecular systems, all sharing common biosynthetic principles. These pathways are key events in the overall cellular physiology, and, according to their crucial role, an increasing number of human diseases are related to impaired biogenesis of FeS proteins.
In this Special Issue of IJMS, the focus will be on the most recent research advances in the field of FeS cluster assembly molecular mechanisms, FeS protein biogenesis and its regulation in numerous organisms, from bacteria to humans, and disease-associated FeS protein defects.
Dr. Paola Costantini
Manuscript Submission Information
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- typical and atypical FeS clusters: biogenesis diversity and evolution
- FeS cluster assembly factors: structure and function
- ISC and CIA assembly machinery
- models and strategies for studying FeS proteins biogenesis
- FeS proteins diseases