Special Issue "Molecular and Translational Research on Bone Tumors"
Deadline for manuscript submissions: 31 December 2021.
Interests: bone cell biology; bone diseases; bone regeneration; mesenchymal stem cells; osteoclasts; osteoblasts; osteocytes; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Recent Advances in Mesenchymal Stem Cell Immunomodulation and Regenerative Medicine 2.0
Special Issue in International Journal of Molecular Sciences: Recent Advances in Mesenchymal Stem Cell Immunomodulation and Regenerative Medicine 3.0
Interests: bone cell biology; bone diseases; osteoclasts; osteoblasts; osteocytes; bone metabolism
Bone tumours can affect every part of the skeleton and can develop in any part of the bone, from the centre to the surface. Their growth can destroy healthy tissue and reduce bone strength, causing pathologic fractures. Primary bone tumours and metastases are characterized by the perturbation of physiological bone remodelling activity by osteoblasts and osteoclasts. The crosstalk between cancer and bone cells allows the growth and the spread of the tumour.
Due to the unknown aetiology, complexity and heterogeneity of most bone tumours, a better understanding of the mechanisms underlying the oncogenesis is still necessary.
This Special Issue will focus both on benign and malignant bone tumours, in particular on:
The analysis of the molecular and cellular mechanisms leading to the onset of these tumours;
The identification of new therapeutic approaches;
The detection of biomarkers for early diagnosis.
Both original research and review articles are welcome.
Dr. Andrea Del Fattore
Dr. Michela Rossi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Primary bone tumours
- Metastatic bone tumour
- Epigenetic factors
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative title: Expression analysis of NHEJ and HR genes in Ewing sarcomas: indications of DSB repair dysfunction
Author: Anastasios Kyriazoglou
Tentative title: Role of phytochemicals in the treatment of bone tumours
Author: Srijit Das
Tentative title: Exploration of endothelial-to-mesenchymal transition EndoMT in osteosarcoma bone tumor microenvironment: Insights from patient samples and in vitro studies
Author: Isabelle Corre
Short Abstract: This study highlights for the first time the process of endothelial-to-mesenchymal transition in osteosarcoma patient-derived tissue samples (diagnostic, surgery, metastasis). In a cellular in vitro model, the secretome from tumor or stromal cells both in naive and therapeutic conditions has been explored as putative inducer of EndoMT
Tentative title: Profiling of extracellular vesicles from tissue explant cultures identifies new prognostic markers and molecular targets in canine osteosarcoma
Author: Alicia Viloria-Petit
Abstract/Summary: Osteosarcoma (OS) is a highly malignant bone tumour that has seen little improvement in treatment modalities in the past 30 years. Understanding what molecules contribute to OS biology could aid in the discovery of novel therapies. Extracellular vesicles serve as a method of cell-to-cell communication, but also have the potential to uncover novel protein signatures. In our research, we developed a novel pipeline to isolate, characterize and profile extracellular vesicles from normal bone and osteosarcoma tissue explants from canine OS patients. Proteomic analysis of vesicle preparations revealed a protein signature related to protein metabolism. One molecule of interest, PSMD14, was explored further given its prognostic potential in human and canine OS and its targetability by an available drug. In vitro experiments demonstrated that PSMD14 targeting induces apoptosis and signficantly inhibit colony formation in two metastatic canine OS cell lines. This unique pipeline can increase our understanding of OS and find new molecular targets for both human and canine OS patients.
Tentative title: Target proteomic approach to identify MMP9 and TGF-beta expressions from high-grade osteosarcoma
Author: Rashmi Akula