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Metal Nanoparticles: Current Advances in Design and Development for Antineoplastic Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 18375

Special Issue Editors

Dr. Mónika Kiricsi

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, Szeged, Hungary
Interests: nanoparticles; nanomedicine; experimental chemotherapy; tumor microenvironment; multidrug resistance; radioresistance; epithelial-mesenchymal transition; transcriptional regulation; combination therapy
Prof. Dr. Imre Miklós Boros

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Hungary
Interests: transcription regulation; chromatin; epigenetics

Special Issue Information

Dear Colleagues,

The rapidly developing field of nanotechnology offers new possibilities for medical uses. In particular, the potential of using metal-based nanoparticles for oncotherapy attracts interest from multidisciplinary areas. Metal nanoparticles exhibit intrinsic cytotoxicity, are ideal tools for drug delivery, radio- and chemosensitization, and could therefore be exploited upon targeted elimination of malignant cells. Although many of the cellular and molecular changes induced by metal-based nanoparticles have been identified, a complete understanding of how the properties of nanoparticles influence interactions with living systems awaits further studies. Research is warranted for the elucidation of the molecular mechanisms triggered by simple and complex metal nanoparticles on multidrug-resistant, radiation-resistant cancer, or cancer stem cells. Likewise, a detailed characterization of the disrupted communication between malignant and stromal cells by nanomaterials in the tumor microenvironment is necessary. Insights and knowledge of these features would shape and refine nanoparticle-based treatment strategies and advances, reaching the ultimate goal of suppressing cancer invasion and metastasis.

This Special Issue is aimed at providing an insight into the latest advances in the field of nanomedicine, with emphasis on the benefits, limitations, and future directions of utilizing metal nanoparticles in oncotherapy. We encourage researchers to share their views and news on these exciting topics. Original research papers and review articles are warmly welcomed.

Dr. Mónika Kiricsi
Prof. Dr. Imre Miklós Boros
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metal nanoparticles
  • Hybrid metal nanoparticles
  • Core-shell metal nanoparticles
  • Antineoplastic activity
  • Suppression of metastasis
  • Molecular mechanism
  • Tumor microenvironment
  • Paracrine communication within the tumor
  • Multidrug resistance
  • Radio-resistance
  • Chemo- and radiosensitization
  • Combination therapy

Published Papers (4 papers)

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Research

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6 pages, 1174 KiB  
Communication
Protein-Mediated Transformations of Superparamagnetic Nanoparticles Evidenced by Single-Particle Inductively Coupled Plasma Tandem Mass Spectrometry: A Disaggregation Phenomenon
by Jacek Sikorski, Magdalena Matczuk, Agnieszka Kamińska, Joanna Kruszewska, Maciej Trzaskowski, Andrei R. Timerbaev and Maciej Jarosz
Int. J. Mol. Sci. 2022, 23(3), 1088; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23031088 - 19 Jan 2022
Cited by 3 | Viewed by 1372
Abstract
Progress toward translating superparamagnetic iron oxide nanoparticles (SPIONs) with specific diagnostic and therapeutic properties for clinical applications depends on developing and implementing appropriate methodologies that would allow in-depth characterizations of their behavior in a real biological environment. Herein, we report a versatile approach [...] Read more.
Progress toward translating superparamagnetic iron oxide nanoparticles (SPIONs) with specific diagnostic and therapeutic properties for clinical applications depends on developing and implementing appropriate methodologies that would allow in-depth characterizations of their behavior in a real biological environment. Herein, we report a versatile approach for studying interactions between SPIONs and proteins using single-particle inductively coupled plasma tandem mass spectrometry. By monitoring the changes in the size distribution upon exposure to human serum, the formation of stable protein corona is revealed, accompanied by particle disaggregation. Full article
(This article belongs to the Special Issue Metal Nanoparticles: Current Advances in Design and Development for Antineoplastic Applications)
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22 pages, 38636 KiB  
Article
Polyvinyl-Pyrrolidone-Coated Silver Nanoparticles—The Colloidal, Chemical, and Biological Consequences of Steric Stabilization under Biorelevant Conditions
by Andrea Rónavári, Péter Bélteky, Eszter Boka, Dalma Zakupszky, Nóra Igaz, Bettina Szerencsés, Ilona Pfeiffer, Zoltán Kónya and Mónika Kiricsi
Int. J. Mol. Sci. 2021, 22(16), 8673; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168673 - 12 Aug 2021
Cited by 25 | Viewed by 2993
Abstract
(1) Background: Several properties of silver nanoparticles (AgNPs), such as cytotoxic, anticancer, and antimicrobial activities, have been subjects of intense research; however, important aspects such as nanoparticle aggregation are generally neglected, although a decline in colloidal stability leads to a loss of the [...] Read more.
(1) Background: Several properties of silver nanoparticles (AgNPs), such as cytotoxic, anticancer, and antimicrobial activities, have been subjects of intense research; however, important aspects such as nanoparticle aggregation are generally neglected, although a decline in colloidal stability leads to a loss of the desired biological activities. Colloidal stability is affected by pH, ionic strength, or a plethora of biomolecules that interact with AgNPs under biorelevant conditions. (2) Methods: As only a few studies have focused on the relationship between aggregation behavior and the biological properties of AgNPs, here, we have systematically evaluated this issue by completing a thorough analysis of sterically (via polyvinyl-pyrrolidone (PVP)) stabilized AgNPs that were subjected to different circumstances. We assessed ultraviolet–visible light absorption, dynamic light scattering, zeta potential measurements, in vitro cell viability, and microdilution assays to screen both colloidal stability as well as bioactivity. (3) Results: The results revealed that although PVP provided outstanding biorelevant colloidal stability, the chemical stability of AgNPs could not be maintained completely with this capping material. (4) Conclusion: These unexpected findings led to the realization that stabilizing materials have more profound importance in association with biorelevant applications of nanomaterials than just being simple colloidal stabilizers. Full article
(This article belongs to the Special Issue Metal Nanoparticles: Current Advances in Design and Development for Antineoplastic Applications)
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Review

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24 pages, 4719 KiB  
Review
Mechanisms of Nanoscale Radiation Enhancement by Metal Nanoparticles: Role of Low Energy Electrons
by Yi Zheng and Léon Sanche
Int. J. Mol. Sci. 2023, 24(5), 4697; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24054697 - 28 Feb 2023
Cited by 1 | Viewed by 1585
Abstract
Metal nanoparticles are considered as highly promising radiosensitizers in cancer radiotherapy. Understanding their radiosensitization mechanisms is critical for future clinical applications. This review is focused on the initial energy deposition by short-range Auger electrons; when high energy radiation is absorbed by gold nanoparticles [...] Read more.
Metal nanoparticles are considered as highly promising radiosensitizers in cancer radiotherapy. Understanding their radiosensitization mechanisms is critical for future clinical applications. This review is focused on the initial energy deposition by short-range Auger electrons; when high energy radiation is absorbed by gold nanoparticles (GNPs) located near vital biomolecules; such as DNA. Auger electrons and the subsequent production of secondary low energy electrons (LEEs) are responsible for most the ensuing chemical damage near such molecules. We highlight recent progress on DNA damage induced by the LEEs produced abundantly within about 100 nanometers from irradiated GNPs; and by those emitted by high energy electrons and X-rays incident on metal surfaces under differing atmospheric environments. LEEs strongly react within cells; mainly via bound breaking processes due to transient anion formation and dissociative electron attachment. The enhancement of damages induced in plasmid DNA by LEEs; with or without the binding of chemotherapeutic drugs; are explained by the fundamental mechanisms of LEE interactions with simple molecules and specific sites on nucleotides. We address the major challenge of metal nanoparticle and GNP radiosensitization; i.e., to deliver the maximum local dose of radiation to the most sensitive target of cancer cells (i.e., DNA). To achieve this goal the emitted electrons from the absorbed high energy radiation must be short range, and produce a large local density of LEEs, and the initial radiation must have the highest possible absorption coefficient compared to that of soft tissue (e.g., 20–80 keV X-rays). Full article
(This article belongs to the Special Issue Metal Nanoparticles: Current Advances in Design and Development for Antineoplastic Applications)
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26 pages, 2160 KiB  
Review
Cancer Therapy by Silver Nanoparticles: Fiction or Reality?
by Dávid Kovács, Nóra Igaz, Mohana K. Gopisetty and Mónika Kiricsi
Int. J. Mol. Sci. 2022, 23(2), 839; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23020839 - 13 Jan 2022
Cited by 51 | Viewed by 11462
Abstract
As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. [...] Read more.
As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. In this review, we highlight those characteristics of silver nanoparticle-based therapeutic concepts that are unique, exploitable, and achievable, as well as those that represent the critical hurdle in their advancement to clinical utilization. The collection of findings presented here will describe the features that distinguish silver nanoparticles from other anti-cancer agents and display the realistic opportunities and implications in oncotherapeutic innovations to find out whether cancer therapy by silver nanoparticles is fiction or reality. Full article
(This article belongs to the Special Issue Metal Nanoparticles: Current Advances in Design and Development for Antineoplastic Applications)
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