Special Issue "Mitochondrial Dynamics in Neurons"
Deadline for manuscript submissions: 31 October 2021.
Interests: mitochondrial DNA; neurodegeneration; mitochondrial dynamics; synaptopathies; mito-nuclear communication
Interests: Alzheimer’s disease; cholesterol in neurodegeneration; mitochondria; mitochondrial oxidative stress; autophagy/mitophagy
The chemical energy provided by the mitochondria is essential for proper neuronal function. Once differentiated, neurons depend on their communication through synaptic transmission to survive, and synapses consume most of the neural energy. To ensure that there is no shortage, neurons send mitochondria from their soma to the energy-hungry synapses through long axonal and dendritic tracts. Conversely, exhausted mitochondria travel long distances back from synapses to the soma to recover. The continuous distribution of mitochondrial energy required by neurons involves several biochemical processes that are closely coordinated by mito-nuclear communication, which adjusts neuronal bioenergetics in an activity-dependent manner. These biochemical processes include mitochondrial fusion, fission, and transport; mitochondrial quality control; and replication, transcription, and translation of mitochondrial DNA. The alteration of any of these processes is at the root of various neurodegenerative diseases. Consequently, the biochemical mechanisms involved in neuronal mitochondrial bioenergetics are now the subject of intense investigation.
The Special Issue “Mitochondrial Dynamics in Neurons” aims to cover research on cellular and molecular mechanisms involved in the regulation of mitochondrial dynamics and the mitochondrial DNA copy number in neurons, including the influence of glial cells on the function of neuronal mitochondria. The Special Issue will also incorporate research that aims to ascertain the role of mito-nuclear communication, mitochondrial quality control, and mitochondrial dynamics in neurodegenerative diseases. The main objective of this Special Issue is to bring together research on the different fields of mitochondrial biology to advance our knowledge of the physio-pathological effects of mitochondria in neuronal function.
Dr. Ramon Trullas
Dr. Anna Colell
Manuscript Submission Information
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- mitochondrial dynamics
- mitochondrial DNA
- mito-nuclear communication
- mitochondrial transport
- mitochondrial oxidative stress
- neurodegenerative disorders
- mitochondrial cholesterol
- neuronal bioenergetics
- mitochondrial fission
- mitochondrial fusion