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Special Issue "Understanding the Molecular Mechanisms of Retinal Ganglion Cell Death after Optic Nerve Damage"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 July 2021.

Special Issue Editor

Dr. Takuji Kurimoto
Guest Editor
Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Japan
Interests: Neuroprotection, retinal ganglion cells, axonal injury, neuronal cell death

Special Issue Information

Dear Colleagues,

The optic nerve is a bundle of axons from retinal ganglion cells (RGCs). Once it is injured, retrograde axonal degeneration occurs, and RGCs finally fall into cell death. Clinically, most optic neuropathies are still resistant to treatments, and beneficial regimens have yet to be established. A variety of animal models, including glaucoma, traumatic optic neuropathy, ischemic optic neuropathy, experimental autoimmune encephalomyelitis, etc., has been applied to elucidate pathological mechanisms. Notably, it has been suggested that RGC death is linked to inflammatory reaction, autophagy, oxidative reaction, mitochondrial dysfunction, and glucose and lactate metabolisms. This Special Issue explores recent advances in order to understand molecular mechanisms of RGC death better and solicits novel perspectives by expert review.

Dr. Takuji Kurimoto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Autophagy
  • Mitochondrial dysfunction
  • inflammatory reaction
  • optic nerve crush/transection
  • glaucoma model
  • ischemic optic neuropathy model
  • Leber hereditary optic neuropathy model
  • glucose metabolism

Published Papers

This special issue is now open for submission.
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