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Molecules and Nanoparticles for Cancer Diagnosis and Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 3793

Special Issue Editors


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Guest Editor
Department of Biomolecular Physics, Faculty of Physics, Babeş-Bolyai University, Kogălniceanu 1, RO-400084 Cluj-Napoca, Romania
Interests: computational spectroscopy; weak inter-molecular interactions; electronic structure of biomolecules (DFT and post Hartree-Fock methods); active pharmaceutical ingredients; vibrational spectroscopy techniques (IR, Raman, SERS); adsorption of molecules on surfaces; photophysics of biomolecules
Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
Interests: plasmonics; nanopaticles and nanostructures; biodetection; fluorescence; nanomedicine; diagnostics and therapy

Special Issue Information

Dear Colleagues,

Cancer remains one of the leading causes of death worldwide, with nearly 19.3 million new diagnoses and an estimated 10.0 million deaths recorded each year [Sung et al., CA Cancer J Clin. 2021, 71, 209–249]. In this context, new and efficient methods are highly needed in terms of accurate imaging techniques for early diagnosis, as well as cancer treatments and their real time monitoring.

The scope of this Special Issue is to collect original and review papers, both experimentally and/or computationally (quantum chemical and molecular dynamics) oriented, related to molecules and nanoparticles for cancer diagnosis and therapy.

The submitted manuscripts are expected to deal with the structure and physicochemical properties of a wide range of compounds, including but not limited to: lead candidates for developing new anticancer drugs, novel PET and SPECT tracers, molecules for photodynamic therapy, natural antioxidants and phytochemicals, and multimodal nanoparticles or nanoparticle-based contrast agents.

Prof. Dr. Vasile Chiş
Dr. Monica Focsan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer diagnosis
  • cancer therapy
  • hybrid nanostructures
  • multimodal nanoparticles
  • theranostic
  • molecular imaging
  • NMR
  • PET
  • SPECT
  • fluorescence imaging
  • photodynamic therapy
  • photothermal therapy
  • contrast agents

Published Papers (1 paper)

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Review

25 pages, 3250 KiB  
Review
Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges
by Andreea Campu, Ilinca Muresan, Ana-Maria Craciun, Simona Cainap, Simion Astilean and Monica Focsan
Int. J. Mol. Sci. 2022, 23(14), 7728; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23147728 - 13 Jul 2022
Cited by 15 | Viewed by 3237
Abstract
Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was [...] Read more.
Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was proposed to overcome the limitations of ECG. In particular, the measurement of troponins, specifically cardiac troponin I (cTnI) and cardiac troponin T (cTnT), has proven to be superior in terms of sensitivity and specificity in the diagnosis of myocardial damage. As one of the most life-threatening conditions, specific and sensitive investigation methods that are fast, universally available, and cost-efficient to allow for early initiation of evidence-based, living-saving treatment are desired. In this review, we aim to present and discuss the major breakthroughs made in the development of cTnI and cTnT specific biosensor designs and analytical tools, highlighting the achieved progress as well as the remaining challenges to reach the technological goal of simple, specific, cheap, and portable testing chips for the rapid and efficient on-site detection of cardiac cTnI/cTnT biomarkers in order to diagnose and treat cardiovascular diseases at an incipient stage. Full article
(This article belongs to the Special Issue Molecules and Nanoparticles for Cancer Diagnosis and Therapy)
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