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Special Issue "Ways to Model Neurologic Disorders: New Insights"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Claudia Compagnucci
Guest Editor
Unit of Molecular Genetics and Functional Genomics, Research Area of Genetics and Rare Diseases, Ospedale Pediatrico Bambino Gesù Viale di San Paolo, 15 00146 Rome, Italy
Interests: Induced pluripotent stem cell; Rare diseases; Cell banking; Cellular phenotyping assays; Neurogenesis; Neurodegeneration
Dr. Emanuela Piermarini
Guest Editor
Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 W Queen Lane 19129 Philadelphia, United States
Interests: Animal models; Behavior Assays; Cytoskeleton; Neurodegeneration; Signalling; Oxidative Stress

Special Issue Information

Dear Colleagues,

Animal models play a fundamental role for understanding the pathogenesis of several human disorders, but not all diseases can be reproduced in animals. For this reason, the development of the induced pluripotent stem cell (iPSC) technology has become relevant for modelling human disorders. Since 2007, many diseases have been modelled by using iPSCs and, most recently, organoids, i.e., three-dimensional multicellular structures arising from iPSCs, which offer the unique opportunity to investigate and understand the complex 3D cellular phenotype of numerous human pathologies. Modelling human disorders is important as it both improves our comprehension of disease pathogenesis and offers the opportunity to test mechanistically constructed therapeutics which may effectively treat and/or prevent neurological disorders.

This Special Issue will focus on recent advances in the generation of human disease models, with particular emphasis on models of neurologic disorders. Articles offering innovative insights into the multifaceted pathophysiology of neurological diseases are welcome. Original research articles and reviews are invited on all aspects of neurological disease modelling, from animal models to models based on human iPSCs and 3D organoids that better represent the in vivo environment.


Dr. Claudia Compagnucci
Dr. Emanuela Piermarini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • disease modelling
  • neurogenesis
  • neurodegeneration
  • pathogenesis
  • induced pluripotent stem cell
  • organoids
  • cellular phenotyping assays
  • animal models
  • molecular mechanisms
  • pharmacologic treatments

Published Papers

This special issue is now open for submission.
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