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Special Issue "The Mechanisms Regulation of the Neuromuscular Dysfunctions"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Dr. Emiliano Ce
E-Mail Website
Guest Editor
Universita degli Studi di Milano, Milan, Italy
Interests: neuromuscular activation; muscle strength; muscle fatigue; muscle stretching; surface electromyography; mechanomyography; electromechanical delay
Special Issues and Collections in MDPI journals

Special Issue Information

Dear colleagues,

The term neuromuscular dysfunction refers to a whole series of alterations in the chain of events that begins with the activation at the cortical level of the motor areas responsible for carrying out movements and ends at the musculoskeletal level with the production of force and the consequent movement development. Possible perturbations in one of these fundamental passages, whether at a central or peripheral level, can lead to an alteration in the generation of the force of a single muscle and to a perturbation of the delicate mechanisms of regulation of the movement itself. Causes of such perturbations can be both physiological (just think of the adaptation mechanisms linked to aging) and pathological, as a common final route of pathologies with different etiological basis, and affecting different systems, e.g., musculoskeletal, neurological, cardiorespiratory, and endocrine.

In recent years, the arrival of new technologies (such as high-density surface electromyography, mechanomyography, transcranial and nerve stimulation, share wave elastography, high frame rate ultrasound, etc.) has made it possible to evaluate in vivo with ever more precision and clarity what the mechanisms underlying some neuromuscular dysfunctions may be, integrating this information with that obtained about the isolated muscle, on the single-fiber or the single-cell. All this has allowed ever-greater integration of information, which has led both to a greater understanding of the phenomenon and, from an applicative point of view, to an increasingly targeted choice of intervention.

With this in mind, this Special Issue will collect original studies that evaluate the deficit at the neuromuscular level through a translational approach, which integrates information from a level of the single fiber or cell up to the study. of the neuromuscular system in vivo. Original research or reviews that address issues related to neuromuscular deficit as a consequence of physiological phenomena (e.g., in the elderly, conditions of microgravity, bed rest) are all welcome.

Dr. Emiliano Ce
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Aging
  • Bed rest
  • Microgravity
  • Disuse
  • Neuromuscular dysfunction: muscle-skeletal system
  • Neuromuscular dysfunction: cardiorespiratory system
  • Neuromuscular dysfunction: endocrine system
  • Neuromuscular dysfunction: neurological system

Published Papers

This special issue is now open for submission.
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