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Neuropeptides and Myopeptides
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Neuropeptides and Myopeptides

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3146

Special Issue Editor

Dr. Vincenzo Monda

E-Mail Website
Guest Editor
Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80100 Naples, Italy
Interests: physiology; nutrition; sports; autonomic nervous system; orexin; exercise

Special Issue Information

Dear colleagues,

Orexin and Irisin are two peptides involved in the normal physiology of nutrition and physical exercise. There are many studies on the functions of orexins, less on those of irisin, but there is no doubt that our knowledge about these is still limited. Broadening this knowledge would undoubtedly open paths to better human health management. For these reasons, I invite you to send papers regarding the role of orexin and/or irisin in regulating the physiology of nutrition and/or exercise, or possible changes that nutrition and/or exercise make on the circulating levels of these peptides, or how these peptides perform basic functions for maintaining health and how we could use them in medicine.

Dr. Vincenzo Monda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Orexin 
  • Irisin 
  • Nutrition 
  • Physical Exercise 
  • Human Healt 
  • Neuropeptides 
  • Myopeptides

Published Papers (1 paper)

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Research

22 pages, 4047 KiB  
Article
Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson’s Disease
by Milos Stanojlovic, Jean Pierre Pallais and Catherine M. Kotz
Int. J. Mol. Sci. 2021, 22(2), 795; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020795 - 14 Jan 2021
Cited by 12 | Viewed by 2799
Abstract
Aside from the classical motor symptoms, Parkinson’s disease also has various non-classical symptoms. Interestingly, orexin neurons, involved in the regulation of exploratory locomotion, spontaneous physical activity, and energy expenditure, are affected in Parkinson’s. In this study, we hypothesized that Parkinson’s-disease-associated pathology affects orexin [...] Read more.
Aside from the classical motor symptoms, Parkinson’s disease also has various non-classical symptoms. Interestingly, orexin neurons, involved in the regulation of exploratory locomotion, spontaneous physical activity, and energy expenditure, are affected in Parkinson’s. In this study, we hypothesized that Parkinson’s-disease-associated pathology affects orexin neurons and therefore impairs functions they regulate. To test this, we used a transgenic animal model of Parkinson’s, the A53T mouse. We measured body composition, exploratory locomotion, spontaneous physical activity, and energy expenditure. Further, we assessed alpha-synuclein accumulation, inflammation, and astrogliosis. Finally, we hypothesized that chemogenetic inhibition of orexin neurons would ameliorate observed impairments in the A53T mice. We showed that aging in A53T mice was accompanied by reductions in fat mass and increases in exploratory locomotion, spontaneous physical activity, and energy expenditure. We detected the presence of alpha-synuclein accumulations in orexin neurons, increased astrogliosis, and microglial activation. Moreover, loss of inhibitory pre-synaptic terminals and a reduced number of orexin cells were observed in A53T mice. As hypothesized, this chemogenetic intervention mitigated the behavioral disturbances induced by Parkinson’s disease pathology. This study implicates the involvement of orexin in early Parkinson’s-disease-associated impairment of hypothalamic-regulated physiological functions and highlights the importance of orexin neurons in Parkinson’s disease symptomology. Full article
(This article belongs to the Special Issue Neuropeptides and Myopeptides)
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