Molecular Mechanism(s) of Non-steroidal Anti-inflammatory Drugs in the Prevention of Metabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 21914
Special Issue Editors
Interests: NSAIDs; cancer chemoprevention; phytochemicals; TGF-beta superfamily; alternative splicing
Interests: eicosanoid biochemistry; cyclooygenase; lipooxygenase; cancer prevention
Special Issue Information
Dear Colleagues,
The prevention of metablolic dieseases such as cancer, obesity, diabetes, and other inflammatory related diseases is an emerging research topic. Considerable research is currently directed toward the development of molecular target-based interventions, and a number of antitumorigenic and anti-inflammatory compounds have been developed and tested. Of these interventions, cyclooxygenase inhibitors have a particularly potent preventive and therapeutic value. Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs that target the activity of cyclooxygenase-1 or cyclooxygenase-2.
NSAIDs modulate not only cyclooxygenase activity but also many regulatory proteins including transcription factors, enzymes, cytokines, and growth factors. NSAIDs are known to be COX-dependent. However, in the last decade, considerable research has been published on the COX-independent pathway to support the hypothesis that NSAIDs may play an important role in other pathways.
This Special Issue is primarily focused on the prevention of metabolic diseases in regard to NSAIDs and their dependency and independency on cyclooxygenases. Future discoveries of NSAIDs and their potential targets in metabolic diseases could in turn establish new discoveries, helping us to understand the mechanisms of these diseases.
Dr. Seung Joon Baek
Dr. Thomas Eling
Guest Editors
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Keywords
- NSAIDs
- Metabolic diseases
- chemoprevention
- COX-dependent and -independent manner