Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Probiotics in Human Health and Diseases
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Probiotics in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 25875

Special Issue Editor

Prof. Dr. Satya Prakash

E-Mail Website
Guest Editor
Faculty of Medicine, McGill University, Montréal, QC, Canada
Interests: bioengineering; artificial cell; biomaterial; drug delivery; microbiome; probiotics; regenerative medicine; cell therapy; health food; GI model; stem cell; heart health; medical device
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Probiotics have shown significant human health benefits for the majority of human diseases. Probiotics are predicted to be useful in the prevention and therapy of diseases such as diabetes, obesity, cancer, cardiovascular dysfunctions, inflammatory bowel diseases, neurological disorders, and other chronic diseases. Significant advancements have been made in microbiome and probiotic research. These include the development of mechanism-based probiotics, novel delivery methods such as micro/nanocapsules and powders, the design of probiotic formulations in food and drinks, and other innovations.

This Special Issue will cover the state of the art of research in probiotics’ role in human health and disease. Both original research articles and reviews on this subject are welcome.

Prof. Dr. Satya Prakash
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Probiotics
  • Microbiome
  • Human Health
  • Live Bacteria
  • Biomedicine
  • Diabetes
  • Obesity
  • Cancers
  • Cardiovascular diseases
  • Inflammatory Bowel Diseases
  • Neurological Disorders
  • Chronic Diseases

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 6473 KiB  
Article
Probiotic Supplementation Suppresses Tumor Growth in an Experimental Colorectal Cancer Liver Metastasis Model
by Matas Jakubauskas, Lina Jakubauskiene, Bettina Leber, Angela Horvath, Kestutis Strupas, Philipp Stiegler and Peter Schemmer
Int. J. Mol. Sci. 2022, 23(14), 7674; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23147674 - 12 Jul 2022
Cited by 4 | Viewed by 1909
Abstract
Colorectal cancer (CRC) ranks third in incidence and second in mortality of all cancers worldwide. At the time of primary diagnosis, around 20% of patients already have metastatic CRC and only around 20% are candidates for radical resection. Thus, most of the patients [...] Read more.
Colorectal cancer (CRC) ranks third in incidence and second in mortality of all cancers worldwide. At the time of primary diagnosis, around 20% of patients already have metastatic CRC and only around 20% are candidates for radical resection. Thus, most of the patients have to undergo chemotherapy (CTx). Due to chemoresistance and side effects, novel treatment additives are crucial for controlling the disease and prolonging patient survival. The aim of this study was to evaluate probiotic supplementation and its antitumorigenic effects in an experimental CRC liver metastasis model. Six-week-old male Wistar rats received either a multispecies probiotic (1.2 × 109 CFU/daily) or placebo mixture. On day 14 of the experiment, rat CRC cells (CC531) were implanted under the liver capsule later treated by FOLFOX CTx. Change in tumor volume was measured by performing micro computed tomography (micro-CT) scanning on experimental days 28 and 34. Additionally, immunohistochemical staining with anti-MPO, anti-Ki67, and anti-CD31 were performed. Tumor apoptosis was evaluated using TUNEL staining. Micro-CT image analysis indicates that probiotic supplementation significantly inhibits tumor growth. No synergistic effects between probiotic supplementation and FOLFOX CTx was observed. Reduced tumor volume was achieved by inhibiting angiogenesis, as tumor microvascular density was significantly lower in rats receiving probiotic supplementation. This study shows that a multispecies probiotic mixture significantly reduces angiogenesis and inhibits CRC liver metastasis growth in an experimental rat model. Full article
(This article belongs to the Special Issue Probiotics in Human Health and Diseases)
►▼ Show Figures

Figure 1

16 pages, 2321 KiB  
Article
Anti-Obesity Efficacy of Pediococcus acidilactici MNL5 in Canorhabditis elegans Gut Model
by Kaliyan Barathikannan, Ramachandran Chelliah, Fazle Elahi, Akanksha Tyagi, Vijayalakshmi Selvakumar, Paul Agastian, Mariadhas Valan Arasu and Deog-Hawn Oh
Int. J. Mol. Sci. 2022, 23(3), 1276; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23031276 - 24 Jan 2022
Cited by 10 | Viewed by 3822
Abstract
In the present study, thirty two lactic acid bacteria (LAB) were isolated from fermented Indian herbal medicine. In comparison to other strains, MNL5 had stronger bile salt hydrolase (BSH) and cholesterol-lowering properties. Furthermore, it can withstand the extreme conditions found in the GI [...] Read more.
In the present study, thirty two lactic acid bacteria (LAB) were isolated from fermented Indian herbal medicine. In comparison to other strains, MNL5 had stronger bile salt hydrolase (BSH) and cholesterol-lowering properties. Furthermore, it can withstand the extreme conditions found in the GI tract, due to, e.g., pepsin, bile salts, pancreatin, and acids. Pediococcus acidilactici MNL5 was identified as a probiotic candidate after sequencing the 16S rRNA gene. The antibacterial activity of P. acidilactici MNL5 cell-free supernatants (CFS) against Escherichia coli, Staphylococcus aureus, Helicobacter pylori, Bacillus cereus, and Candida albicans was moderate. A Caenorhabditis elegans experiment was also performed to assess the effectiveness of P. acidilactici MNL5 supplementation to increase life span compared to E. coli supplementation (DAF-2 and LIU1 models) (p < 0.05). An immense reduction of the lipid droplets of C. elegans was identified through a fluorescent microscope. The drastic alteration of the expression of fat genes is related to obesity phenotypes. Hence, several paths are evolutionary for C. elegans; the results of our work highlight the nematode as an important model for obesity. Full article
(This article belongs to the Special Issue Probiotics in Human Health and Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

28 pages, 584 KiB  
Review
Evaluating the Role of Probiotics in the Prevention and Management of Age-Related Diseases
by Despoina E. Kiousi, Antonia Z. Kouroutzidou, Konstantinos Neanidis, Dimitrios Matthaios, Aglaia Pappa and Alex Galanis
Int. J. Mol. Sci. 2022, 23(7), 3628; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073628 - 26 Mar 2022
Cited by 1 | Viewed by 3276
Abstract
The human lifespan has been significantly increased due to scientific advancements in the management of disease; however, the health span of the aging population does not follow the same trend. Aging is the major risk factor for multimorbidity that is derived from the [...] Read more.
The human lifespan has been significantly increased due to scientific advancements in the management of disease; however, the health span of the aging population does not follow the same trend. Aging is the major risk factor for multimorbidity that is derived from the progressive loss of homeostasis, immunological and stem cell exhaustion, as well as exacerbated inflammation responses. Age-related diseases presenting with high frequencies include neurodegenerative, musculoskeletal, cardiovascular, metabolic diseases and cancer. These diseases can be co-morbid and are usually managed using a disease-specific approach that can eventually lead to polypharmacy, low medication adherence rates and undesired drug-drug interactions. Novel studies suggest targeting the shared biological basis of age-related diseases to retard the onset and manage their manifestations. Harvesting the anti-inflammatory and immunomodulatory capacity of probiotics to tackle the root cause of these diseases, could pose a viable alternative. In this article, a comprehensive review of the effects of probiotic supplementation on the molecular pathogenesis of age-related diseases, and the potential of probiotic treatments as preventative or alleviatory means is attempted. Furthermore, issues on the safety and efficiency of probiotic supplementation, as well as the pitfalls of current clinical studies are discussed, while new perspectives for systematic characterization of probiotic benefits on aged hosts are outlined. Full article
(This article belongs to the Special Issue Probiotics in Human Health and Diseases)
►▼ Show Figures

Figure 1

19 pages, 1514 KiB  
Review
Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases
by Mahmoud Youssef, Hanaa Y. Ahmed, Abel Zongo, Ali Korin, Fuchao Zhan, Essam Hady, Muhammad Umair, Muhammad Shahid Riaz Rajoka, Yongai Xiong and Bin Li
Int. J. Mol. Sci. 2021, 22(20), 11290; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011290 - 19 Oct 2021
Cited by 11 | Viewed by 6935
Abstract
Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires [...] Read more.
Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires inexpensive, novel, and safe therapeutics. Therefore, scientists have paid close attention to probiotics as safe remedies to combat these morbidities owing to their health benefits and biotherapeutic effects. Probiotics have been broadly adopted as functional foods, nutraceuticals, and food supplements to improve human health and prevent some morbidity. Intriguingly, recent research indicates that probiotics are a promising solution for treating and prophylactic against certain dangerous diseases. Probiotics could also be associated with their essential role in animating the immune system to fight COVID-19 infection. This comprehensive review concentrates on the newest literature on probiotics and their metabolism in treating life-threatening diseases, including immune disorders, pathogens, inflammatory and allergic diseases, cancer, cardiovascular disease, gastrointestinal dysfunctions, and COVID-19 infection. The recent information in this report will particularly furnish a platform for emerging novel probiotics-based therapeutics as cheap and safe, encouraging researchers and stakeholders to develop innovative treatments based on probiotics to prevent and treat chronic and viral diseases. Full article
(This article belongs to the Special Issue Probiotics in Human Health and Diseases)
►▼ Show Figures

Figure 1

53 pages, 951 KiB  
Review
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
by Laura Marinela Ailioaie and Gerhard Litscher
Int. J. Mol. Sci. 2021, 22(9), 4942; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094942 - 06 May 2021
Cited by 31 | Viewed by 8613
Abstract
In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial [...] Read more.
In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body. Full article
(This article belongs to the Special Issue Probiotics in Human Health and Diseases)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop