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Dear Colleagues,

Selenium (Se) is a trace element with a pivotal role in redox homeostasis and functions in human health that are not fully characterized. Additionally, inorganic selenocompounds along with small organic molecules containing Se have demonstrated multiple activities in CNS-related illnesses and many other diseases through a plethora of mechanisms. This Special Issue will cover different steps of the development process (from the design and evaluation to the molecular characterization of the mechanism of action) of novel inorganic and organic selenoderivatives as bioactive compounds for human diseases. We firmly believe that the latest research into selenoderivatives and their biological effects should shed some light for gaining further knowledge about the interconnection of this class of compounds and illnesses such as cancer, parasitic diseases, Alzheimer’s disease and Parkinson’s disease, among others. Thus, the development of novel selenoderivatives could represent a novel and promising approach to developing more potent and safer bioactive agents.

Prof. Dr. Carmen Sanmartín
Prof. Dr. Maria Javier Ramirez
Dr. Daniel Plano Amatriain
Prof. Dr. Arun Sharma
Guest Editors

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Keywords

selenoderivatives
cancer
Alzheimer
Parkinson
parasitic diseases

Published Papers (2 papers)

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Research

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23 pages, 4078 KiB

Open AccessArticle

Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety

by Vladimir Burmistrov, Christophe Morisseau, Denis A. Babkov, Tatiana Golubeva, Dmitry Pitushkin, Elena V. Sokolova, Vladimir Vasipov, Yaroslav Kuznetsov, Sergey V. Bazhenov, Uliana S. Novoyatlova, Nikolay A. Bondarev, Ilya V. Manukhov, Victoria Osipova, Nadezhda Berberova, Alexander A. Spasov, Gennady M. Butov and Bruce D. Hammock

Int. J. Mol. Sci. 2022, 23(18), 10710; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms231810710 - 14 Sep 2022

Cited by 5 | Viewed by 1870

Abstract

The inhibitory potency of the series of inhibitors of the soluble epoxide hydrolase (sEH) based on the selenourea moiety and containing adamantane and aromatic lipophilic groups ranges from 34.3 nM to 1.2 μM. The most active compound 5d possesses aliphatic spacers between the selenourea group and lipophilic fragments. Synthesized compounds were tested against the LPS-induced activation of primary murine macrophages. The most prominent anti-inflammatory activity, defined as a suppression of nitric oxide synthesis by LPS-stimulated macrophages, was demonstrated for compounds 4a and 5b. The cytotoxicity of the obtained substances was studied using human neuroblastoma and fibroblast cell cultures. Using these cell assays, the cytotoxic concentration for 4a was 4.7–18.4 times higher than the effective anti-inflammatory concentration. The genotoxicity and the ability to induce oxidative stress was studied using bacterial lux-biosensors. Substance 4a does not exhibit genotoxic properties, but it can cause oxidative stress at concentrations above 50 µM. Put together, the data showed the efficacy and safety of compound 4a. Full article

(This article belongs to the Special Issue Selenium and Selenoderivatives as Emerging Bioactive Agents for Human Diseases)

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Review

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28 pages, 2892 KiB

Open AccessReview

Therapeutic Benefits of Selenium in Hematological Malignancies

by Melanie A. Ehudin, Upendarrao Golla, Devnah Trivedi, Shobha D. Potlakayala, Sairam V. Rudrabhatla, Dhimant Desai, Sinisa Dovat, David Claxton and Arati Sharma

Int. J. Mol. Sci. 2022, 23(14), 7972; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23147972 - 19 Jul 2022

Cited by 7 | Viewed by 3175

Abstract

Supplementing chemotherapy and radiotherapy with selenium has been shown to have benefits against various cancers. This approach has also been shown to alleviate the side effects associated with standard cancer therapies and improve the quality of life in patients. In addition, selenium levels in patients have been correlated with various cancers and have served as a diagnostic marker to track the efficiency of treatments or to determine whether these selenium levels cause or are a result of the disease. This concise review presents a survey of the selenium-based literature, with a focus on hematological malignancies, to demonstrate the significant impact of selenium in different cancers. The anti-cancer mechanisms and signaling pathways regulated by selenium, which impart its efficacious properties, are discussed. An outlook into the relationship between selenium and cancer is highlighted to guide future cancer therapy development. Full article

(This article belongs to the Special Issue Selenium and Selenoderivatives as Emerging Bioactive Agents for Human Diseases)

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