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Special Issue "Signaling in Melanoma 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Malgorzata Czyz
E-Mail Website
Guest Editor
Department of Molecular Biology of Cancer, Medical University of Lodz, Lodz, Poland
Interests: melanoma; genome; phenotype
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Melanoma is highly heterogeneous, with cell subpopulations exerting transcriptionally distinct phenotypes. It is a consequence of diverse genetic alterations, but also of non-genomic changes often induced by the tumor microenvironment. These changes are integrated into the active modifications of multiple signaling pathways, including, but not limited to, the mitogen-activated protein kinase (MAPK) pathway and phosphoinositol-3-kinase (PI3K) pathway, which license melanoma cell survival, progression, and drug resistance. An analysis of the clinical samples derived from the melanoma patients that developed resistance to targeted therapies or immunotherapies created the opportunity to follow the changes in several critical signaling pathways.

This Special Issue of the International Journal of Molecular Sciences aims to bring together the state-of-the-art views and original research on “Signaling in Melanoma”. It will focus on the alterations in the signaling pathways that are crucial for melanoma initiation and progression, interactions of melanoma cells with the tumor microenvironment, and the development of resistance to targeted therapies and immunotherapies.

Dr. Malgorzata Czyz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • melanoma
  • immunotherapy
  • targeted therapy
  • signaling pathways
  • tumor microenvironment

Published Papers

This special issue is now open for submission.
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