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Special Issue "Skin Epidermis and Barrier Function 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Prof. Dr. Kyung-Min Lim
E-Mail
Guest Editor
College of Pharmacy, Ewha Womans University, Seoul, Korea
Interests: skin; cosmetics; whitening; anti-aging; atopic dermatitis; alternative to animal test methods; irritation
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the first edition on “Skin Epidermis and Barrier Function” which presented 13 high-quality papers.

The skin epidermis is the most superficial epithelial tissue that protects our body from the outer environment. Human skin epidermis has evolved to form an effective barrier against external obnoxious stimuli that may enter the body and the loss of internal moisture. Complex differentiation/proliferation processes orchestrate the maturation of the epidermis, and various molecules participate in skin barrier function. The disruption of epidermal homeostasis is closely linked to various skin diseases that include xerosis, atopic dermatitis, psoriasis, and skin squamous cell carcinoma. Consequently, the skin epidermis is of high interest to dermatology, pathology, pharmacology, toxicology, molecular biology, and the cosmetic sciences. This Special Issue entitled “Skin Epidermis and Barrier Function” invites research studies on various aspects of the skin epidermis and its barrier function at the molecular level.

Prof. Dr. Kyung-Min Lim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Skin epidermis
  • Stratum corneum
  • Corneocytes, keratinocytes
  • Epidermal differentiation/proliferation
  • Skin barrier function, skin barrier dysfunction
  • Epidermal lipids, ceramide, free fatty acid, cholesterol, natural moisturizing factor
  • Filaggrin, loricrin, involucrin, keratin, corneodesmosome
  • Tight junction
  • Atopic dermatitis, eczema
  • Dry skin, psoriasis
  • Squamous cell carcinoma
  • Skin stem cell

Published Papers (1 paper)

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Research

Open AccessArticle
UV-Irradiation- and Inflammation-Induced Skin Barrier Dysfunction Is Associated with the Expression of Olfactory Receptor Genes in Human Keratinocytes
Int. J. Mol. Sci. 2021, 22(6), 2799; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22062799 - 10 Mar 2021
Viewed by 332
Abstract
Olfactory receptors (ORs) have diverse physiological roles in various cell types, beyond their function as odorant sensors in the olfactory epithelium. These previous findings have suggested that ORs could be diagnostic markers and promising therapeutic targets in several pathological conditions. In the current [...] Read more.
Olfactory receptors (ORs) have diverse physiological roles in various cell types, beyond their function as odorant sensors in the olfactory epithelium. These previous findings have suggested that ORs could be diagnostic markers and promising therapeutic targets in several pathological conditions. In the current study, we sought to characterize the changes in the expression of ORs in the HaCaT human keratinocytes cell line exposed to ultraviolet (UV) light or inflammation, well-recognized stimulus for skin barrier disruption. We confirmed that major olfactory signaling components, including ORs, GNAL, Ric8b, and adenylate cyclase type 3, are highly expressed in HaCaT cells. We have also demonstrated that the 12 ectopic ORs detectable in HaCaT cells are more highly expressed in UV-irradiated or inflamed conditions than in normal conditions. We further assessed the specific OR-mediated biological responses of HaCaT cells in the presence of known odorant ligands of ORs and observed that specific ligand-activated ORs downregulate skin barrier genes in HaCaT cells. This study shows the potential of OR as a marker for skin barrier abnormalities. Further research is needed to explore how OR is implicated in the development and progression of barrier dysfunction. Full article
(This article belongs to the Special Issue Skin Epidermis and Barrier Function 2.0)
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