Dear Colleagues,

Since the introduction of iPSC technology by Yamanaka et al., hopes for these pluripotent stem cells were initially raised towards using these cells as a source for regenerative therapy. As the field has evolved, these cells have, through more advanced differentiation protocols and with the introduction of CRISPR/Cas technology, shown to be even more useful in establishing in vitro human disease models. More advanced differentiation models have also opened up the technology for a wider spectrum of tissues. In addition, the technology has been taken beyond the initial in vitro reprogramming of fibroblasts to other cell types (e.g., mononuclear leukocytes). The initial cell source to reprogram has evolved as a field of its own. Beyond the initial in vitro reprogramming, the technology has also been proven for in vivo reprogramming in, for example, heart tissue.

In parallel, more recent advancements in the development of the bioengineering of patch and graph technology have again raised the initial hopes of iPSCs to be sources for tissue regeneration.

For this Special Issue, we would like to invite papers that follow this concept: to use iPSC-derived cells in new disease models, new techniques for differentiation and maturation beyond what has already been done, as well as advancement in implantation techniques or bioengineered constructs based on iPSC technology.

Interesting concepts include but are not limited to:

• Mature cardiomyocytes;
• ß-cells;
• Neuron and subtypes of neurons;
• Neural supportive tissue;
• New sources of cells to reprogram;
• In vivo reprogramming.

Prof. Stefan Jovinge
Guest Editor

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• reprogramming
• in vivo reprogramming
• human disease models
• ß-cells
• glia cells
• astrocytes
• iBMEC
• neurons
• cardiomyocytes
• hepatocytes
• iPSC bio-engineering