Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0

Dear Colleagues, 

Liver injury by potentially toxic exogenous and endogenous compounds represents major molecular, mechanistic, and medical challenges. Among the hepatotoxic exogenous compounds are conventional drugs, herbal drugs including various traditional herbal products and so-called herbal supplements lacking supplementary features in patients with a normal balanced diet, alcoholic beverages, industrial chemicals such as aliphatic halogenated hydrocarbons like carbon tetrachloride, environmental chemicals such as heavy metals, nature-based products, and compounds ingested with some fungi. Endogenous hepatotoxic compounds are found in individuals suffering from hereditary diseases such as hemochromatosis caused by iron overload, Wilson disease due to copper overload, Gaucher disease caused by accumulation of glucocerebroside, hepatic porphyria due to metabolic problems of hem synthesis, and a vast range of other hereditary diseases. Finally, much interest has focused more recently on molecular, mechanistic, and clinical aspects on overweight patients with nonalcoholic fatty liver disease and progression to nonalcoholic steatonecrosis (NASH) and nonalcoholic liver cirrhosis, including rare hepatocellular carcinoma. Submissions to the International Journal of Molecular Sciences with a current IF of 4.5 are welcome with focus on molecular, mechanistic, and medical challenges; discouraged are purely clinical papers. 

Prof. Dr. Rolf Teschke
Guest Editor

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• liver injury

• nonalcoholic fatty liver disease
• nonalcoholic steatonecrosis
• nonalcoholic liver cirrhosis
• hepatocellular carcinoma